Synapsin-1 (D12G5) XP® Rabbit mAb

5297:

IHC / Paraffin , Immunofluorescence , Immunoprecipitation , Western Blotting

Synapsin-1 (D12G5) XP^® Rabbit mAb detects endogenous levels of total synapsin protein. The antigen is 100% conserved between human synapsin-1a and synapsin-1b.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln483 of human synapsin-1 protein.

Synapsins, a group of at least five related members (synapsins Ia, Ib, IIa, IIb, and IIIa), are abundant brain proteins essential for regulating neurotransmitter release (1,2). All synapsins contain a short amino-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I (1). Phosphorylation of the synapsin amino-terminal domain at Ser9 inhibits its binding to phospholipids and dissociates synapsins from synaptic vesicles (2).

1. Greengard, P. (1987) Mol Neurobiol 1, 81-119.
2. Hosaka, M. et al. (1999) Neuron 24, 377-87.

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For Research Use Only. Not For Use In Diagnostic Procedures.