PINK1 (D8G3) Rabbit mAb

6946:

Immunoprecipitation , Western Blotting

PINK1 (D8G3) Rabbit mAb recognizes endogenous levels of total PINK1 protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro140 of human PINK1 protein.

PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria (1-3). PINK1 phosphorylates Parkin and promotes its translocation to mitochondria (2). Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction (1,3).

1. Liu, W. et al. (2009) PLoS One 4, e4597.
2. Kim, Y. et al. (2008) Biochem Biophys Res Commun 377, 975-80.
3. Petit, A. et al. (2005) J Biol Chem 280, 34025-32.

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For Research Use Only. Not For Use In Diagnostic Procedures.