组织 cDNA 芯片介绍
组织 cDNA 芯片是一个包含肿瘤和癌旁组织 cDNA 的阵列，可以直接用于实时荧光定量 PCR，检测目的基因（包括 mRNA、microRNA、circRNA 和 lncRNA）在不同样本中的表达。现有产品涵盖肺癌、食管癌、胃癌、结肠癌和肝癌。
组织 cDNA 芯片四大优势
1、更高的科研效率
1）无需费时费力收集组织样本、抽提及反转录；
2）可直接进行 qPCR 验证。
2、更完整的临床信息
1）样本具有详细的临床；
2）随访信息。
3、更可靠的实验结果
1）严格质控、高质量 RNA；
2）看家基因 Actin 水平验证。
4、更多水平验证
1）配套的石蜡样本组织芯片；
2）帮助实现基因、蛋白水平双重验证。
组织 cDNA 芯片制作流程
看家基因 β-actin qPCR
产品案例 qPCR
近几年发表的相关文献
Lehtinen L, Vainio P, Wikman H, Huhtala H, Mueller V, Kallioniemi A, Pantel K, Kronqvist P, Kallioniemi O, Carpen O et al: PLA2G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells. The journal of pathology Clinical research 2017, 3(2):123-138.
Young HL, Rowling EJ, Bugatti M, Giurisato E, Luheshi N, Arozarena I, Acosta JC, Kamarashev J, Frederick DT, Cooper ZA et al: An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition. The Journal of experimental medicine 2017, 214(6):1691-1710.
Blake A, Dragan M, Tirona RG, Hardy DB, Brackstone M, Tuck AB, Babwah AV, Bhattacharya M: G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance. Scientific reports 2017, 7:46525.
Tseng HY, Chen YA, Jen J, Shen PC, Chen LM, Lin TD, Wang YC, Hsu HL: Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression. Oncogenesis 2017, 6(4):e313.
Mo D, Fang H, Niu K, Liu J, Wu M, Li S, Zhu T, Aleskandarany MA, Arora A, Lobo DN et al: Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway. Cancer research 2016, 76(10):3057-3066.
Kajita K, Kuwano Y, Satake Y, Kano S, Kurokawa K, Akaike Y, Masuda K, Nishida K, Rokutan K: Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells. Oncogenesis 2016, 5:e213.
Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV: Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer research 2016, 76(13):3884-3894.
Kajita K, Kuwano Y, Satake Y, Kano S, Kurokawa K, Akaike Y, Masuda K, Nishida K, Rokutan K: Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells. Oncogenesis 2016, 5:e213.
Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY: Regulation of breast tumorigenesis through acid sensors. Oncogene 2016, 35(31):4102-4111
Gobel A, Thiele S, Browne AJ, Rauner M, Zinna VM, Hofbauer LC, Rachner TD: Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells. Cancer letters 2016, 375(1):162-171.
Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, Wang YS, Chao KC, Wang LH: Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nature communications 2015, 6:5917.
Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA: Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic acids research 2015, 43(4):2353-2366.
Kim Y, Kim J, Jang SW, Ko J: The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer. Oncogene 2015, 34(2):226-236.
组织 cDNA 芯片是一个包含肿瘤和癌旁组织 cDNA 的阵列，可以直接用于实时荧光定量 PCR，检测目的基因（包括 mRNA、microRNA、circRNA 和 lncRNA）在不同样本中的表达。现有产品涵盖肺癌、食管癌、胃癌、结肠癌和肝癌。
组织 cDNA 芯片四大优势
1、更高的科研效率
1）无需费时费力收集组织样本、抽提及反转录；
2）可直接进行 qPCR 验证。
2、更完整的临床信息
1）样本具有详细的临床；
2）随访信息。
3、更可靠的实验结果
1）严格质控、高质量 RNA；
2）看家基因 Actin 水平验证。
4、更多水平验证
1）配套的石蜡样本组织芯片；
2）帮助实现基因、蛋白水平双重验证。
组织 cDNA 芯片制作流程
看家基因 β-actin qPCR
产品案例 qPCR
近几年发表的相关文献
Lehtinen L, Vainio P, Wikman H, Huhtala H, Mueller V, Kallioniemi A, Pantel K, Kronqvist P, Kallioniemi O, Carpen O et al: PLA2G7 associates with hormone receptor negativity in clinical breast cancer samples and regulates epithelial-mesenchymal transition in cultured breast cancer cells. The journal of pathology Clinical research 2017, 3(2):123-138.
Young HL, Rowling EJ, Bugatti M, Giurisato E, Luheshi N, Arozarena I, Acosta JC, Kamarashev J, Frederick DT, Cooper ZA et al: An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition. The Journal of experimental medicine 2017, 214(6):1691-1710.
Blake A, Dragan M, Tirona RG, Hardy DB, Brackstone M, Tuck AB, Babwah AV, Bhattacharya M: G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance. Scientific reports 2017, 7:46525.
Tseng HY, Chen YA, Jen J, Shen PC, Chen LM, Lin TD, Wang YC, Hsu HL: Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression. Oncogenesis 2017, 6(4):e313.
Mo D, Fang H, Niu K, Liu J, Wu M, Li S, Zhu T, Aleskandarany MA, Arora A, Lobo DN et al: Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway. Cancer research 2016, 76(10):3057-3066.
Kajita K, Kuwano Y, Satake Y, Kano S, Kurokawa K, Akaike Y, Masuda K, Nishida K, Rokutan K: Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells. Oncogenesis 2016, 5:e213.
Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV: Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer research 2016, 76(13):3884-3894.
Kajita K, Kuwano Y, Satake Y, Kano S, Kurokawa K, Akaike Y, Masuda K, Nishida K, Rokutan K: Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells. Oncogenesis 2016, 5:e213.
Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY: Regulation of breast tumorigenesis through acid sensors. Oncogene 2016, 35(31):4102-4111
Gobel A, Thiele S, Browne AJ, Rauner M, Zinna VM, Hofbauer LC, Rachner TD: Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells. Cancer letters 2016, 375(1):162-171.
Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, Wang YS, Chao KC, Wang LH: Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nature communications 2015, 6:5917.
Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA: Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic acids research 2015, 43(4):2353-2366.
Kim Y, Kim J, Jang SW, Ko J: The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer. Oncogene 2015, 34(2):226-236.
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