1. Although a multitude of mechanisms have been proposed, there are no studies evaluating the impact of……
2. …has previously been demonstrated to be required for……
3. the role of ….underlying……remain to be defined…
4. Finally, we provide evidence that these observations are applicable in vivo by demonstrating…..
5. With refinement in….methodology, it has been possible to…
6. Several attempts have been made to….
7. This report presents observation…..
8. to study the cellular mechanisms influencing……
9. XXX provide a useful in vitro system to study the cellular mechanisms involved in
10. …has limited their usefulness for in vitro studies of ……
11. this in vitro model system may be especially useful for studying the cellular mechanisms for …action in …as well as identifying……
12. to address this concern,……
13. We demonstrate for the first time that…These therapeutic effects were mediated by……. These findings suggest the……could represent an innovative therapeutic option for treating diabetic neuropathy
14. ...is an increasingly recognized phenomenon in…. Recently, reports have been published that……It is unclear whether……. We sought to determine the relationship between……We hypothesized that…
15. Further research is needed to define….
16. The impact of …on…is unclear. The objective of this study was to evaluate the incremental effect of……
17. …has been deemed……However, this …….event appears to be under‐recognized and is worth being investigated further.
19. with regard to…..there is already ample evidence for the existence of…
20. It is an attractive hypothesis that…
21. This implies that…..could slow the development of….through complementary mechanisms.
22. although data are accumulating to show that……
23. The data acquired from these studies might give insight into achieving
24. The successful demonstration of…. encourages us to propose that…. The remaining challenge is to establish a protocol to generate….
25. …has emerged as a powerful tool to study aspects of….
26. Efforts in our laboratory investigating the….. With little or no data to indicate which molecules may be important in…
27. To circumvent these difficulties some studies have eschewed whole cell proteomics, employing a more focused approach…
28、We have undertaken…. In support of this effort, we have devised a novel approach to generate…
29、To overcome this constraint…. To further examine the utility of this approach,
30、These observations provide strong evidence for cross‐talk between….and…
31、There is evidence from experimental and animal studies for an interaction between…and… in atherogenesis.
32、based on these considerations,
33、Our previous studies have shown that… This study was designed to examine the regulation by oxLDL of the expression of…in HCAEC.
34、Incubation/pretreatment of…cells with…for…hours increase the expression of…(mRNA and protein) in a concentration and time‐dependent manner with maximal expression at….
35、A number of investigators have shown that…the effects of OxLDL in vascular cells are mediated by….
36、Previous studies from our lab have shown that….others have shown that inhibition of…in…blocked the effects of oxldl.
37、Although… there is little information on its association with……
38、A statistically significantly interaction between…and…suggested that…
39、In analysis, there is evidence of linear associations between…and…. A linear increase of …. Was observed
40、There are limited data on…
41、Diabetes increases the morbidity/mortality of …disease, but the underlying mechanisms are incompletely understood.
42、… but whether AMPK is cardioprotective or a central mediator of adiponectin cardio protection in vivo remains unknown.
43 、 Collectively, our results demonstrated that AMPK deficiency significantly increases MI/R injury in vivo but has minimal effect on the antioxidative protection of adiponectin.
44、however, the mechanism of this observation is not fully clarified.
45、 The present study indicates that extracellular nucleotide–mediated eNOS phosphorylation is calcium and protein kinase C dependent. This newly identified signaling pathway opens new therapeutic avenues for the treatment of endothelial dysfunction.
46、To elucidate the signaling pathway leading to…….cells were treated with several drugs, including ………, in the presence or absence of selective inhibitors.
47、…have no overall effect on the incidence of…..CHD events In women with established…
48、Coronary outcomes were assessed by….. The effect of raloxifene on the incidence of coronary events differed significantly by age.
449、….. but its clinical utility is uncertain. Essentially no reclassification improvement was found with the addition of…result in a statistically significant improvement in the c‐index
50、The present analysis was conducted to validate the association between…and… no significant associations between…and… was observed….
51、 We sought to assess whether associations exist between…and…. Similar reductions were seen…remained sustained…
52、The present study was performed to determine whether oxidative stress could mediate…
53、…elicited markedly greater reductions in…
54、The influences of antiplatelet therapy discontinuation on the risk of stent thrombosis and long‐term clinical outcomes after drug‐eluting stent implantation have not yet been addressed adequately.
55、…did not suggest an apparent clinical benefit of….
56、Flow‐mediated dilatation testing provides an integrated vascular measure that may aid the prediction of structural disease evolution and represents a potential short‐ to intermediat ‐term outcome measure for evaluation of preventive treatment strategies.
57、…increased significantly…. although the increment was much attenuated in….
58、May therefore provide a missing link between….and….
59、Taken collectively, specifically, mechanistically, importantly, more recently Interestingly, Intriguingly, strikingly,
60、to further establish a link between….and…… we further determined….
61、cells are treated concomitantly with….and….
62、We previously reported repression of….in…cells after treatment with…. This prompted our interest to study…. It is of considerable interest /importance that….
63、….efficiently and specifically/selectively reduce….
64、to put these results into perspective, previous reports by….investigators have provided convincing data supporting a role for….in the generation of foam cell and the development of AS.
65 、 these data are particularly strong for….furthermore, a recent study in which… demonstrated that….
66、It is conceivable that…/…conceivably,
67、despite the robustness of the observation that….a number of issues need to be considered to interpret these data.
68、Interestingly, no significant differences in ….were observed between….
69、There is yet another important conceptual idea that needs to be addressed.
70、In this latter scenario, /in the context of AS,
71、Despite…it is not clear why the study from ….yields conclusions different from those of other investigators.
72、the argument against this hypothesis is that,
73、the observed benefits have generally been attributed to the lowering of….
74、alternatively,
75、There are at least three possible explanations for the absence of an incremental reduction in…in mice receiving…:
76、lead to a plethora of lipid independent effects involving
77、however, several facts argue against the concept that ….induced lowering of LDL‐C does not produce additional vascular benefit beyond that of statins.
78、These close relationship between …..and cardiovascular risk has subsequently been corroborated in several other studies.
79、This finding is further supported by the observation that…
80、On the basis of this information…also in view of…. as confirmed by…. as exemplified by…equally
81、the treatment of patients with…has witnessed profound changes. Currently, the majority of patients are treated with…
82、Thus, it is not unexpected that….in our study was lower than that observed in …and in most other previous lipid‐modifying trials, with the exception of…
83、In further support of the influence of previous statin therapy,…a finding that contrasts with the…
84、these data raised the possibility that…
85、the reason for the failure to observe an incremental effect on…despite a reduction in levels of LDL‐C remains unknown.
86、a minor and non‐significant suppression (5%‐10% relative to control) of…protein after incubation with…was found.
87、our data indicate that…We (present study) and others have shown that….
88、These observations mirror the data obtained from…this study provide the first set of data on…..
89、…significantly suppressed…greatly reduced…markedly diminished….
90、appears to play crucial roles in atherosclerotic plaque rupture. We previously reported that…are elevated in…are prominently expressed in atherosclerotic lesions.
91、The in vivo findings are consistent with results obtained ex vivo…
92、XXX of note/ it would be interesting to note that……
93 、 The current in vivo findings linking…to…support the observation that. Elevated…resulted in….
94、Previous experiments performed in….mice, demonstrated that…as evidenced by….
95、confirming in vitro findings with in vivo results will no doubt further elucidate the pathological role of …in vascular diseases.
96、have become part of clinical armamentarium in the treatment of cardiovascular disease.
97、Treatment of….cells with…led to activation of inflammatory genes including…
98 、 The inductions of these genes induced by….was LOX‐1 dependent as demonstrated by their attenuations in cells transfected with LOX‐1siRNA.
99、Our study identifies and characterize the direct interaction between..and… and suggest….
100、These results together with our preliminary observations that….suggest a role of…in the regulation of vascular Lox‐1 in…
2. …has previously been demonstrated to be required for……
3. the role of ….underlying……remain to be defined…
4. Finally, we provide evidence that these observations are applicable in vivo by demonstrating…..
5. With refinement in….methodology, it has been possible to…
6. Several attempts have been made to….
7. This report presents observation…..
8. to study the cellular mechanisms influencing……
9. XXX provide a useful in vitro system to study the cellular mechanisms involved in
10. …has limited their usefulness for in vitro studies of ……
11. this in vitro model system may be especially useful for studying the cellular mechanisms for …action in …as well as identifying……
12. to address this concern,……
13. We demonstrate for the first time that…These therapeutic effects were mediated by……. These findings suggest the……could represent an innovative therapeutic option for treating diabetic neuropathy
14. ...is an increasingly recognized phenomenon in…. Recently, reports have been published that……It is unclear whether……. We sought to determine the relationship between……We hypothesized that…
15. Further research is needed to define….
16. The impact of …on…is unclear. The objective of this study was to evaluate the incremental effect of……
17. …has been deemed……However, this …….event appears to be under‐recognized and is worth being investigated further.
19. with regard to…..there is already ample evidence for the existence of…
20. It is an attractive hypothesis that…
21. This implies that…..could slow the development of….through complementary mechanisms.
22. although data are accumulating to show that……
23. The data acquired from these studies might give insight into achieving
24. The successful demonstration of…. encourages us to propose that…. The remaining challenge is to establish a protocol to generate….
25. …has emerged as a powerful tool to study aspects of….
26. Efforts in our laboratory investigating the….. With little or no data to indicate which molecules may be important in…
27. To circumvent these difficulties some studies have eschewed whole cell proteomics, employing a more focused approach…
28、We have undertaken…. In support of this effort, we have devised a novel approach to generate…
29、To overcome this constraint…. To further examine the utility of this approach,
30、These observations provide strong evidence for cross‐talk between….and…
31、There is evidence from experimental and animal studies for an interaction between…and… in atherogenesis.
32、based on these considerations,
33、Our previous studies have shown that… This study was designed to examine the regulation by oxLDL of the expression of…in HCAEC.
34、Incubation/pretreatment of…cells with…for…hours increase the expression of…(mRNA and protein) in a concentration and time‐dependent manner with maximal expression at….
35、A number of investigators have shown that…the effects of OxLDL in vascular cells are mediated by….
36、Previous studies from our lab have shown that….others have shown that inhibition of…in…blocked the effects of oxldl.
37、Although… there is little information on its association with……
38、A statistically significantly interaction between…and…suggested that…
39、In analysis, there is evidence of linear associations between…and…. A linear increase of …. Was observed
40、There are limited data on…
41、Diabetes increases the morbidity/mortality of …disease, but the underlying mechanisms are incompletely understood.
42、… but whether AMPK is cardioprotective or a central mediator of adiponectin cardio protection in vivo remains unknown.
43 、 Collectively, our results demonstrated that AMPK deficiency significantly increases MI/R injury in vivo but has minimal effect on the antioxidative protection of adiponectin.
44、however, the mechanism of this observation is not fully clarified.
45、 The present study indicates that extracellular nucleotide–mediated eNOS phosphorylation is calcium and protein kinase C dependent. This newly identified signaling pathway opens new therapeutic avenues for the treatment of endothelial dysfunction.
46、To elucidate the signaling pathway leading to…….cells were treated with several drugs, including ………, in the presence or absence of selective inhibitors.
47、…have no overall effect on the incidence of…..CHD events In women with established…
48、Coronary outcomes were assessed by….. The effect of raloxifene on the incidence of coronary events differed significantly by age.
449、….. but its clinical utility is uncertain. Essentially no reclassification improvement was found with the addition of…result in a statistically significant improvement in the c‐index
50、The present analysis was conducted to validate the association between…and… no significant associations between…and… was observed….
51、 We sought to assess whether associations exist between…and…. Similar reductions were seen…remained sustained…
52、The present study was performed to determine whether oxidative stress could mediate…
53、…elicited markedly greater reductions in…
54、The influences of antiplatelet therapy discontinuation on the risk of stent thrombosis and long‐term clinical outcomes after drug‐eluting stent implantation have not yet been addressed adequately.
55、…did not suggest an apparent clinical benefit of….
56、Flow‐mediated dilatation testing provides an integrated vascular measure that may aid the prediction of structural disease evolution and represents a potential short‐ to intermediat ‐term outcome measure for evaluation of preventive treatment strategies.
57、…increased significantly…. although the increment was much attenuated in….
58、May therefore provide a missing link between….and….
59、Taken collectively, specifically, mechanistically, importantly, more recently Interestingly, Intriguingly, strikingly,
60、to further establish a link between….and…… we further determined….
61、cells are treated concomitantly with….and….
62、We previously reported repression of….in…cells after treatment with…. This prompted our interest to study…. It is of considerable interest /importance that….
63、….efficiently and specifically/selectively reduce….
64、to put these results into perspective, previous reports by….investigators have provided convincing data supporting a role for….in the generation of foam cell and the development of AS.
65 、 these data are particularly strong for….furthermore, a recent study in which… demonstrated that….
66、It is conceivable that…/…conceivably,
67、despite the robustness of the observation that….a number of issues need to be considered to interpret these data.
68、Interestingly, no significant differences in ….were observed between….
69、There is yet another important conceptual idea that needs to be addressed.
70、In this latter scenario, /in the context of AS,
71、Despite…it is not clear why the study from ….yields conclusions different from those of other investigators.
72、the argument against this hypothesis is that,
73、the observed benefits have generally been attributed to the lowering of….
74、alternatively,
75、There are at least three possible explanations for the absence of an incremental reduction in…in mice receiving…:
76、lead to a plethora of lipid independent effects involving
77、however, several facts argue against the concept that ….induced lowering of LDL‐C does not produce additional vascular benefit beyond that of statins.
78、These close relationship between …..and cardiovascular risk has subsequently been corroborated in several other studies.
79、This finding is further supported by the observation that…
80、On the basis of this information…also in view of…. as confirmed by…. as exemplified by…equally
81、the treatment of patients with…has witnessed profound changes. Currently, the majority of patients are treated with…
82、Thus, it is not unexpected that….in our study was lower than that observed in …and in most other previous lipid‐modifying trials, with the exception of…
83、In further support of the influence of previous statin therapy,…a finding that contrasts with the…
84、these data raised the possibility that…
85、the reason for the failure to observe an incremental effect on…despite a reduction in levels of LDL‐C remains unknown.
86、a minor and non‐significant suppression (5%‐10% relative to control) of…protein after incubation with…was found.
87、our data indicate that…We (present study) and others have shown that….
88、These observations mirror the data obtained from…this study provide the first set of data on…..
89、…significantly suppressed…greatly reduced…markedly diminished….
90、appears to play crucial roles in atherosclerotic plaque rupture. We previously reported that…are elevated in…are prominently expressed in atherosclerotic lesions.
91、The in vivo findings are consistent with results obtained ex vivo…
92、XXX of note/ it would be interesting to note that……
93 、 The current in vivo findings linking…to…support the observation that. Elevated…resulted in….
94、Previous experiments performed in….mice, demonstrated that…as evidenced by….
95、confirming in vitro findings with in vivo results will no doubt further elucidate the pathological role of …in vascular diseases.
96、have become part of clinical armamentarium in the treatment of cardiovascular disease.
97、Treatment of….cells with…led to activation of inflammatory genes including…
98 、 The inductions of these genes induced by….was LOX‐1 dependent as demonstrated by their attenuations in cells transfected with LOX‐1siRNA.
99、Our study identifies and characterize the direct interaction between..and… and suggest….
100、These results together with our preliminary observations that….suggest a role of…in the regulation of vascular Lox‐1 in…
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