文献支持HA600075·Anti-YKL-40/CHI3L1 Antibody [A3G13]

靶点 ：YKL-40/CHI3L1

浓度 ：2 mg/mL.

应用范围 ：WB

适应物种 ：Human

保质期 ：1年

供应商 ：Huabio

标记物 ：Non-conjugated

保存条件 ：Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

形态 ：Liquid

亚型 ：IgG1

免疫原 ：Recombinant protein within extracellular domainof human CHI3L1.

规格 ：50μl/100μl

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.