信号转导和转录激活因子6重组兔单克隆抗体

价格： ￥1800

品牌：Biorigin

货号：BN42114R

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适应物种：Human,Mouse,

应用范围：WB，FCM，

抗体英文名：STAT6

规格：50ul

英文名称	STAT6
中文名称	信号转导和转录激活因子6重组兔单克隆抗体
别名	signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.
研究领域	肿瘤发育生物学信号转导细胞凋亡转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	9A7
交叉反应	Human, Mouse,
产品应用	WB=1:500-1000 IHC-P=1:20-200 IHC-F=1:20-200 Flow-Cyt=2ug/Test ICC=1:20-200 IF=1:20-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	94kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human STAT6 protein, around 700-800aa:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif. Subcellular Location: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated following stimulation by IL-4 and IL-3. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. SWISS: P42226 Gene ID: 6778 Database links: Entrez Gene: 6778 Human Entrez Gene: 20852 Mouse Entrez Gene: 362896 Rat Omim: 601512 Human SwissProt: P42226 Human SwissProt: P52633 Mouse Unigene: 524518 Human Unigene: 121721 Mouse Unigene: 6880 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.