甲状腺激素受体α抗体

适应物种 ：Human,Mouse,Rat,Chicken,Pig,Horse,Rabbit,Sheep,Guinea Pig,

应用范围 ：WB,

抗体英文名 ：Thyroid hormone receptor alpha

规格 ：100ul

英文名称	Thyroid hormone receptor alpha
中文名称	甲状腺激素受体α抗体
别    名	AR7; c-erbA-1; C-erbA-alpha; CHNG6; EAR 7; EAR-7; EAR7; ERB-T-1; ERBA alpha; ERBA; ERBA Related 7; ERBA-related 7; ERBA1; NR1A1; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA 1; THRA; THRA1; THRA2; Thyroid hormone receptor alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor; V-erbA-related protein 7.

 

 

 

研究领域	细胞生物  神经生物学  信号转导  生长因子和激素  内分泌病
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat,  (predicted: Chicken, Pig, Horse, Rabbit, Sheep, Guinea Pig, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	55kDa
细胞定位	细胞核
性    状	Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human Thyroid hormone receptor alpha:81-180/490
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Thyroid hormone receptors (TR) are ligand dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha 1 and TR alpha 2, and TR beta 1 and TR beta 2 respectively. TR alpha 1 and 2 are identical through amino acid 370, where their sequences diverge. TR alpha 2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha 1. Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Subunit: Interacts with ncoa2. Subcellular Location: Nucleus. Tissue Specificity: After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P10827 Gene ID: 7067 Database links: Entrez Gene: 7067 Human Entrez Gene: 21833 Mouse Entrez Gene: 81812 Rat Omim: 190120 Human SwissProt: P10827 Human SwissProt: P63058 Mouse SwissProt: P63059 Rat Unigene: 724 Human Unigene: 265917 Mouse Unigene: 442648 Mouse Unigene: 11307 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.