半胱氨酸蛋白酶抗体

适应物种 ：Human,Mouse,Rat,Dog,Cow,Horse,

应用范围 ：FCM,

抗体英文名 ：Legumain

规格 ：100ul

英文名称	Legumain
中文名称	半胱氨酸蛋白酶抗体
别    名	AEP; Asparaginyl endopeptidase; EC 3.4.22.34; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1; LGMN_HUMAN.
研究领域	肿瘤  细胞生物  免疫学  细胞凋亡  激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat,  (predicted: Dog, Cow, Horse, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=3ug/Test （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	46kDa
细胞定位	细胞浆
性    状	Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human Legumain:201-300/433
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]. Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Subcellular Location: Lysosome (By similarity). Tissue Specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta. Post-translational modifications: Glycosylated. Similarity: Belongs to the peptidase C13 family. SWISS: Q99538 Gene ID: 5641 Database links: Entrez Gene: 5641 Human Entrez Gene: 19141 Mouse Entrez Gene: 63865 Rat Omim: 602620 Human SwissProt: Q99538 Human SwissProt: O89017 Mouse SwissProt: Q9R0J8 Rat Unigene: 726036 Human Unigene: 17185 Mouse Unigene: 206021 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.