G蛋白偶联受体43抗体

适应物种 ：Human,Mouse,Rat,Pig,Rabbit,

应用范围 ：WB,

抗体英文名 ：GPR43

规格 ：100ul

英文名称	GPR43
中文名称	G蛋白偶联受体43抗体
别    名	GPCR GPR43; FFA2R; Ffar2; FFAR2_HUMAN; free fatty acid activated receptor 2; Free fatty acid receptor 2; G protein coupled receptor 43; G protein-coupled receptor 43; G-protein coupled receptor 43; GPR 43; GPCR 43.
研究领域	细胞生物  信号转导  G蛋白偶联受体  G蛋白信号
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	(predicted: Human, Mouse, Rat, Pig, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	31kDa
细胞定位	细胞膜
性    状	Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human GPR43:21-120/330 <Extracellular>
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	G protein-coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor (GPR) GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice. GPR43 functions as a ligand for short chain fatty acids (SCFAs), notably acetate and propionate. Bacteria in the gut produce high concentrations of SCFAs, which are subsequently released in the bloodstream, where they exert cellular effects on blood leukocytes, including calcium release, ERK1/2 activation, and inhibition of cAMP accumulation. These effects indicate a role for GPR43 in the recruitment of leukocytes, particularly polymorphonuclear cells, to sites of bacterial infection. Function: Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. Subcellular Location: Cell membrane. Tissue Specificity: Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: O15552 Gene ID: 2867 Database links: Entrez Gene: 2867 Human Omim: 603823 Human SwissProt: O15552 Human Unigene: 248056 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.