促黄体激素诱导蛋白抗体

适应物种 ：Human,Mouse,Rat,Pig,Horse,

应用范围 ：IHC-P,

抗体英文名 ：StAR

规格 ：100ul

英文名称	StAR
中文名称	促黄体激素诱导蛋白抗体
别    名	StARD1; Cholesterol trafficker; Luteinizing hormone induced protein; Mitochondrial steroid acute regulatory protein; StAR related lipid transfer (START) domain containing 1; StARD1; START domain containing protein 1; Steroidogenic Acute Regulatory Protein; Steroidogenic acute regulatory protein mitochondrial; STAR_HUMAN.

 

 

研究领域	肿瘤  免疫学  转录调节因子  激酶和磷酸酶  线粒体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat,  (predicted: Pig, Horse, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	32kDa
细胞定位	细胞浆 线粒体
性    状	Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human StAR:181-285/285
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]. Function: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. Subunit: May interact with TSPO. Subcellular Location: Mitochondrion. DISEASE: Defects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma rennin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted. Similarity: Contains 1 START domain. SWISS: P49675 Gene ID: 6770 Database links: Entrez Gene: 6770 Human Entrez Gene: 20845 Mouse Entrez Gene: 25557 Rat Omim: 600617 Human SwissProt: P49675 Human SwissProt: P51557 Mouse SwissProt: P97826 Rat Unigene: 521535 Human Unigene: 293314 Mouse Unigene: 11399 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.