PKAα/β/γ cat Polyclonal Antibody/PKAα/β/γ cat Polyclonal Antibody

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英文名 ：PKAα/β/γ cat Polyclonal Antibody

库存 ：现货

供应商 ：亚科因

CAS号 ：Null

规格 ：30μl///100μl///200μl

关键词：PKAα/β/γ cat抗体;cAMP依赖蛋白激酶催化亚基α/β/γ抗体;cAMP依赖蛋白激酶催化亚基α/β/γ;PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; PRKACG; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma;ABP52222

中文名称：cAMP依赖蛋白激酶催化亚基α/β/γ多克隆抗体/PKAα/β/γ cat Polyclonal Antibody

英文名称：PKAα/β/γ cat Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP52222.pdf

产品描述：兔抗-cAMP依赖蛋白激酶催化亚基α/β/γ 多克隆抗体

PRKACA encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of PRKACA caused either by somatic mutations, or genomic duplications of regions that include PRKACA, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

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