血管内皮生长因子A 兔多克隆抗体/VEGF Rabbit Polyclonal Antibody

保存条件 ：详情请咨询

保质期 ：详情请咨询

英文名 ：VEGF Rabbit Polyclonal Antibody

库存 ：现货

供应商 ：亚科因

CAS号 ：Null

规格 ：30μl///100μl///200μl

关键词：VEGF抗体;血管内皮生长因子A 兔抗体;血管内皮生长因子A 兔;VEGFA;ABP57460

中文名称：血管内皮生长因子A 兔多克隆抗体/VEGF Rabbit Polyclonal Antibody

英文名称：VEGF Rabbit Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP57460.pdf

产品描述：兔抗-血管内皮生长因子A 兔 多克隆抗体

VEGFA (vascular endothelial growth factor A) is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of VEGFA in mice resulted in abnormal embryonic blood vessel formation. VEGFA is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of VEGFA have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

Abbkine致力于为全球生命科学研究和医疗发展提供前沿的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品以及蛋白纯化产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为全球的科学家节省时间并提高研究效率。