V-Rel网状内皮增生病毒癌基因同源物B多克隆抗体/RelB Polyclonal Antibody

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英文名 ：RelB Polyclonal Antibody

库存 ：现货

供应商 ：亚科因

CAS号 ：Null

规格 ：30μl///100μl///200μl

关键词：RelB抗体;V-Rel网状内皮增生病毒癌基因同源物B抗体;V-Rel网状内皮增生病毒癌基因同源物B;RELB; Transcription factor RelB; I-Rel;ABP56029

中文名称：V-Rel网状内皮增生病毒癌基因同源物B多克隆抗体/RelB Polyclonal Antibody

英文名称：RelB Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP56029.pdf

产品描述：兔抗-V-Rel网状内皮增生病毒癌基因同源物B 多克隆抗体

Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: relA, c-Rel, RelB, NF-κB1 (p105/p50， and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleus.

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