PCSK9 [生物素标记] : LDL R 抑制剂筛选检测试剂盒(ELISA)

保存条件 ：Upon receipt, please store all items at -70°C.After reconstitution, the stock solution should be kept at -70°C.

英文名 ：PCSK9 [Biotinylated] : LDL R Inhibitor Screening ELISA Assay Pair

库存 ：1

供应商 ：ACROBiosystems

规格 ：96tests

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).