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免疫原 :A synthetic peptide from the internal region of SMAD4 which includes the mutation of R361H, human origin.
亚型 :lgG
形态 :液体
保存条件 :-20℃
克隆性 :单克隆
标记物 :FITC
适应物种 :脊椎动物
保质期 :24个月
抗原来源 :蛋白
目录编号 :TD-26422
级别 :科研级
库存 :999
供应商 :武汉天德
宿主 :Mouse
应用范围 :ELISA, WB, IHC
浓度 :1mg/ml
靶点 :R361H
抗体英文名 :Anti SMAD4(R361H) Mouse Monoclonal Antibody
抗体名 :SMAD4(R361H)
规格 :100 μL
SMAD4(R361H)
Cat. #: TD-26422 |
Gene Symbol: SMAD4, DPC4, JIP, MADH4, MYHRS |
Description: Anti-SMAD4(R361H) Mouse Monoclonal Antibody |
Background: SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-β signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiple colorectal cancers and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominant disease juvenile polyposis syndrome (JPS). |
Immunogen: A synthetic peptide from the internal region of SMAD4 which includes the mutation of R361H, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: |
Purity: Purified from ascites |
Preservative: no |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes R361H mutant, but not wild type SMAD4 of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot:
Western blot analysis of recombinant SMAD4(R361H) and wild type proteins. Purified His-tagged SMAD4(R361H) protein (lane2) and corresponding wild type protein (lane1) were blotted with Anti-SMAD4(R361H) monoclonal antibody (Cat. #TD-26422).
Immunofluorescence:
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入驻年限:5年