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CP-471474

CAS No. : 210755-45-6

MCE 国际站：CP-471474

产品活性：CP-471474 是一个口服有效的、广泛的 MMP 抑制剂，IC₅₀ 值分别为1170 nM (MMP-1)、0.7 nM (MMP-2)、16 nM (MMP-3)、13 nM (MMP-9) 和 0.9 nM (MMP-13)。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP

In Vivo: CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose).
CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both.
CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months.

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