文献支持HA600010·Anti-HIV1 p24 Antibody

靶点 ：HIV1 p24

浓度 ：2 mg/mL.

应用范围 ：ELISA(Cap),WB

宿主 ：Mouse

适应物种 ：HIV1

保质期 ：1年

供应商 ：Huabio

标记物 ：Non-conjugated

保存条件 ：Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

形态 ：Liquid

亚型 ：IgG1

免疫原 ：Recombinant protein within HIV1 p24 protein aa 133-363 (Catalog#HA210278).

规格 ：50μl/100μl

One distinctive HIV antigen is a viral protein called p24, a structural protein that makes up most of the HIV viral core, or 'capsid'. There are approximately 2000 molecules per virus particle, or at a molecule weight of 24 kDa, about 104 virus particles per picogram of p24. The onset of symptoms of AIDS correlates with a reduction in the number of CD4+ T-cells and increased levels of virus and p24 in the blood. It is a component of the gag polyprotein. High levels of p24 are present in the blood serum of newly infected individuals during the short period between infection and seroconversion, making p24 antigen assays useful in diagnosing primary HIV infection. Antibodies to p24 are produced during seroconversion, rendering p24 antigen undetectable after seroconversion in most cases. Therefore, p24 antigen assays are not reliable for diagnosing HIV infection after its very earliest stages. Fourth-generation HIV immunoassays detect viral p24 protein in the blood (as well as patient antibodies against the virus). Previous generation tests relied on detecting patient antibodies alone; it takes about 3–4 weeks for the earliest antibodies to be detected. The p24 protein can be detected in patient blood as early as 2 weeks after HIV infection, further reducing the window period necessary to accurately detect the HIV status of the patient.