Anti-HIV1 gp120 Polyclonal Antibody

免疫原 ：KLH conjugated synthetic peptide derived from HIV1 Surface protein gp120

亚型 ：IgG

形态 ：冻干粉

保存条件 ：Store at -20°C. Avoid freeze / thaw cycles.

克隆性 ：单克隆

标记物 ：Cell membrane

适应物种 ：HIV-1 M:B_MN

保质期 ：现询客服

抗原来源 ：KLH conjugated synthetic peptide derived from HIV1 Surface protein gp120

库存 ：999

宿主 ：Rabbit

应用范围 ：WB ELISA IHC-F IF

浓度 ：WB 1:500-2000. ELISA 1:500-1000. IHC-F 1:100-500. IF 1:100-500.

靶点 ：HIV1 gp120

抗体英文名 ：Anti-HIV1 gp120 Polyclonal Antibody

抗体名 ：HIV-1 ENV (gp120);HIV1 gp120;HIV1gp120;HIV-1 gp120;Envelope surface glycoprotein gp120;Glycoprotein 120;gp120;gp120 glycoprotein;Human Immunodeficiency Virus 1;SU;Surface protein

规格 ：50ul/100ul

The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. TXN, another PDI family member could also be involved in disulfide rearrangements in Env during fusion. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.