p16(MM116)鼠单克隆抗体

抗体名 ：p16(MM116)鼠单克隆抗体

抗体英文名 ：p16 Mouse Monoclonal Antibody, clone MM116

靶点 ：p16

应用范围 ：IHC

宿主 ：鼠

适应物种 ：人

保质期 ： 1年

供应商 ：优睿赛思（武汉）生物科技有限公司

克隆性 ：单克隆

保存条件 ：Shipped at 4°C. Store at +4°C short term (2-4 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

形态 ：液体

亚型 ：IgG

免疫原 ：Full length recombinant human p16 protein

应用/Application

背景/background
The p16 (p16INK4A) protein is a cyclindependent  kinase  (CDK)  inhibitor that plays  an important  regulatory  role in the cell  cycle. By controlling  the  transition between the G1  and S phases through regulation of retinoblastoma protein, p16decelerates  cellular  differentiation and therefore acts  as a tumor suppressor, making it the  key  marker  in  several   human cancers including head and neck cancer,  perianal  lesions,  melanomas, gliomas, lymphomas, and some types ofleukemia. p16 is also clinically indicated in carcinomas of the esophagus, pancreas, lung, biliary tract, liver, colon, and urinary bladder.