猫、狗慢性肾病检测试剂盒

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供应商 ：天津阿斯尔生物科技有限公司

保存条件 ：2-8℃保存

Symmetric dimethylarginine is a methylated arginine amino acid. Symmetric dimethylarginine is derived from intranuclear methylation of L-arginine residues and is released into the cytoplasm after proteolysis. Symmetric dimethylarginine is excreted by the kidneys.
对称二甲基精氨酸是一种甲基化的精氨酸，它来自于L -精氨酸残基的核内甲基化，在蛋白水解后释放到细胞质中，由肾脏排出。

Several studies have found that 1 in 3 cats and 1 in 10 dogs are likely to develop a kidney disease during their lifetime.
几项研究发现，每3只猫和每10只狗中就有1只可能在它们的一生中患上肾病。

Symmetric dimethylarginine is an early biomarker of kidney function. It correlates well with glomerular filtration rate (GFR). On average, symmetric dimethylarginine increases in chronic kidney disease (CKD) with 30 to 40% loss of kidney function. Creatinine, however, does not increase until 75% of kidney function is lost. Symmetric dimethylarginine will enable veterinarians to diagnose chronic kidney disease (CKD) much earlier than Creatinine or Cystatin C tests.
对称二甲基精氨酸是肾脏功能的早期生物标志物。它与肾小球滤过率(GFR)有很好的相关性。平均而言，肾功能丧失30 - 40%的慢性肾病(CKD)患者中，对称二甲基精氨酸增加。然而，直到75%的肾功能丧失，肌酐才会增加。兽医检测对称二甲基精氨酸将比肌酐或胱抑素C测试更早地诊断慢性肾脏疾病(CKD)。

Symmetric dimethylarginine is specific for kidney function. It is not impacted by other diseases such as liver disease, cardiovascular disease, inflammatory disease and endocrine diseases. Another exciting feature of symmetric dimethylarginine is that it is not impacted by muscle mass either, which simplifies diagnosing and monitoring CKD in thin geriatric animals, especially cats and animals with other diseases that cause muscle wasting.
对称二甲基精氨酸对肾功能有特异性。不受肝病、心血管疾病、炎症、内分泌疾病等疾病的影响。对称二甲基精氨酸另一个令人兴奋的特点是它也不受肌肉质量的影响，这简化了对瘦的老年动物，特别是猫和患有其他导致肌肉萎缩疾病的动物CKD的诊断和监测。

The competitive symmetric dimethylarginine-ELISA uses the microtiter plate format. Symmetric dimethylarginine is bound to the solid phase of the microtiter plate. Symmetric dimethylarginine in the samples is acylated and competes with solid phase bound Symmetric dimethylarginine for a fixed number of rabbit anti-symmetric dimethylarginine antiserum binding sites. When the system is in equilibrium, free antigen and free antigen-antiserum complexes are removed by washing. The antibody bound to the solid phase symmetric dimethylarginine is detected by anti-rabbit / peroxidase. The substrate TMB / peroxidase reaction is monitored at 450 nm. The amount of antibody bound to the solid phase symmetric dimethylarginine is inversely proportional to the symmetric dimethylarginine concentration of the sample.
竞争性的对称二甲基精氨酸-ELISA试剂盒采用微孔板检测。对称二甲基精氨酸与微孔板的固相结合。样品中的对称二甲基精氨酸被酰基化，并与固相结合的对称二甲基精氨酸竞争固定数量的兔抗对称二甲基精氨酸抗血清结合位点。当系统处于平衡状态时，通过洗涤去除游离抗原和游离抗原-抗血清复合物。通过抗兔/过氧化物酶检测与固相对称二甲基精氨酸结合的抗体。在450 nm处检测底物TMB /过氧化物酶反应。与固相对称二甲基精氨酸结合的抗体量与样品中对称二甲基精氨酸浓度成反比。
仅供科研使用。