SARS-CoV-2 重组蛋白

SARS-CoV-2是一种单链RNA的β冠状病毒，包含S、E、M、N四种典型结构蛋白，通过S蛋白来附着并侵入宿主细胞，S蛋白包括S1和S2两个亚基，其中S1亚基上的RBD位点可以与人体肺部细胞表面的ACE2结合，使病毒膜与宿主细胞膜融合而完成入侵过程。因此，S蛋白是疫苗设计、治疗性抗体和诊断方法的关键靶标，而SARS-CoV-2 S、S1、S RBD、human ACE2等蛋白的质量和应用是抗病毒药物开发的关键。
ACROBiosystems基于HEK293的人源细胞表达平台开发出了近50种高质量的SARS-CoV-2相关蛋白产品，经ELISA/MALS/SPR/BLI等技术验证，确认其天然结合活性。
诊断专用蛋白

1. > 可定制，克级供应
2. > 纯度高，批间差异小
3. > 胶体金和酶联免疫验证

三聚体S蛋白

1. > 分子量和聚体形式经验证
2. > 天然结合活性经验证
3. > 可正确发挥生物学功能

生物素标记蛋白

1. > 独特Avitag™技术
2. > 标记均一，天然活性
3. > 纯度高，批间差异小

病毒抗原蛋白

1. > 天然构象，糖基化修饰完整
2. > 纯度高，批间差异小
3. > 活性经验证

相关宿主ACE2蛋白

1. > 纯度高，批间差异小
2. > 结合活性高
3. > 多种属可供选择

验证数据
Cat.No.: SPN-C52H8   Product: SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His Tag, active trimer (MALS verified)

Fig.3 The purity of SARS-CoV-2 S protein (R683A, R685A), His Tag, active trimer (Cat. No. SPN-C52H8) was more than 80% and around 550-660 kDa verified by SEC-MALS.

Fig.4 Human ACE2, Fc Tag (Cat. No. AC2-H5257) Captured on CM5 chip via anti-human IgG Fc antibodies surface can bind SARS-CoV-2 S protein (R683A, R685A), His Tag, active trimer (Cat. No. SPN-C52H8) with an affinity constant of 35.3 nM as determined in a SPR assay (Biacore 8K).
 

Molecule	Cat. No.	Species	Host	Product Description
ACE2	AC2-H82E6	Human	HEK293	Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
	AC2-H82F9	Human	HEK293	Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™
	AC2-H5257	Human	HEK293	Human ACE2 / ACEH Protein, Fc Tag (MALS verified)
	AC2-C52H7	Cynomolgus	HEK293	Cynomolgus ACE2 / ACEH Protein, His Tag
	AC2-H52H8	Human	HEK293	Human ACE2 / ACEH Protein, His Tag (MALS verified)
	AC2-R5246	Rat	HEK293	Rat ACE2 / ACEH Protein, His Tag (MALS verified)
	AC2-M5248	Mouse	HEK293	Mouse ACE2 / ACEH Protein, His Tag (MALS verified)
	AC2-P5248	Paguma larvata	HEK293	Paguma larvata ACE2 / ACEH Protein, His Tag
S protein	SPN-C52H8	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein (R683A, R685A) , His Tag, active trimer (MALS verified)
	SPN-S52H5	SARS	HEK293	SARS S protein (R667A), His Tag
S1 protein	S1N-C52H3	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein, His Tag
	S1N-C82E8	SARS-CoV-2	HEK293	Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified)
	S1N-S52H5	SARS	HEK293	SARS S1 protein, His Tag (MALS verified)
	S1N-C52H4	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified)
	S1N-C5255	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein, Fc Tag
	S1N-C5257	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein, Mouse IgG2a Fc Tag
	S1N-C5256	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag
	SIN-V52H3	HCoV-NL63	HEK293	HCoV-NL63 S1 protein, His Tag
	SIN-V52H4	HCoV-229E	HEK293	HCoV-229E S1 protein, His Tag
S2 protein	S2N-C52H5	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S2 protein, His Tag
S protein RBD	SPD-C82E9	SARS-CoV-2	HEK293	Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified)
	SPD-C5255	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD, Fc Tag (MALS verified)
	SPD-S52H6	SARS	HEK293	SARS S protein RBD, His Tag (MALS verified)
	SPD-C52H3	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)
	SPD-C5259	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag
	SPD-S52H4	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag
	SPD-S52H5	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag
	SPD-S52H7	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag
	SPD-S52H8	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag
	SPD-S52H3	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (N354D, D364Y), His Tag
	SPD-C52H4	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (G476S), His Tag
	SPD-C52H5	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S protein RBD (V483A), His Tag
S1 protein CTD	S1D-C52H3	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein CTD, His Tag
S1 protein NTD	S1D-C52H6	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein NTD, His Tag
Nucleocapsid protein	NUN-C51H9	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag
	NUN-C5227	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag
	NUN-C81Q6	SARS-CoV-2	E.coli	Biotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™
Envelope protein	ENN-C5128	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) Envelope protein, GST,His Tag
Papain-like Protease	PAE-C5148	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) Papain-like Protease Protein, His Tag
NSP1	NS1-C51H7	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag
NSP7	NS7-C51H6	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) NSP7 Protein, His Tag
NSP8	NS8-C5149	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) NSP8 Protein, His Tag
NSP7 & NSP8	NS8-C5125	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) NSP7&NSP8 Protein, His Tag
NSP16 & NSP10	NS0-C51W3	SARS-CoV-2	E.coli	SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag
S protein RBD	SPD-M52H6	MERS	HEK293	MERS S protein RBD, His Tag
S1 protein	SIN-V52H5	HCoV-OC43	HEK293	HCoV-OC43 S1 protein, His Tag
	SIN-V52H6	HCoV-HKU1(isolate N5)	HEK293	HCoV-HKU1(isolate N5) S1 protein, His Tag
	S1N-C82E3	SARS-CoV-2	HEK293	SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™
Nucleocapsid protein	NUN-V52H3	HCoV-OC43	HEK293	HCoV-OC43 Nucleocapsid protein, His Tag
	NUN-V52H4	HCoV-HKU1(isolate N5)	HEK293	HCoV-HKU1(isolate N5) Nucleocapsid protein, His Tag
	NUN-V52H6	HCoV-NL63	HEK293	HCoV-NL63 Nucleocapsid protein, His Tag
	NUN-V52H8	HCoV-229E	HEK293	HCoV-229E Nucleocapsid protein, His Tag
	NUN-M52H5	MERS	HEK293	MERS Nucleocapsid protein, His Tag