Anti-phospho-CENP-A (Ser7), clone NL41; 100 μL

价格：询价

货号：04-792

产品详情

相关推荐

应用范围：Multiplexing;Western Blotting

宿主：Rabbit

抗原来源：0

库存：大量

适应物种：Human

是否单克隆：1

规格：100 μL

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	Mplex, WB, IC	Rabbit	Culture Supernatant	Monoclonal Antibody

Description:

Anti-phospho-CENP-A (Ser7), clone NL41

Replaces:

Cat. # 05-792. 05-792 will only be availabe on a custom basis.

Background Information:

Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.

Clone:

clone NL41

Specificity:

CENP-A phosphorylated on serine 7

Key Applications:

Multiplexing
Western Blotting
Immunocytochemistry

Species Reactivity:

Human

Species Reactivity Note:

Human. Others not tested.

Isotype:

IgG

Immunogen:

peptide containing the sequence RRpSRK in which pS is phospho-serine corresponding to amino acid 7 of human CENP-A (centromere protein A)

Modifications:

Phosphorylation

Molecular Weight:

~17kDa

Control:

Acid extracted proteins from colcemid-arrested HeLa cells

Presentation:

Cultured supernantant in 0.05% sodium azide

Storage Conditions:

Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Gene Symbol:

CENPA
CENP-A

Quality Assurance:

routinely evaluated by immunoblot on acid extracted proteins from colcemid-arrested HeLa cells (Catalog #17-306)

Antibody Category:

Epigenetics & Nuclear Function

Antibody Sub-Category:

Cell Cycle, DNA Replication & Repair

Usage Statement:

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Trade Name:

Upstate (Millipore)

Antibody Type:

Monoclonal Antibody

Format:

Culture Supernatant

Host:

Rabbit

Product Overview:

CENP-A is a variant version of histone H3 found only at centromeres. It is phosphorylated at serine 7 during mitosis.

更多产品技术资讯，请访问密理博中国博客：http://blog.milliporechina.com

peptide containing the sequence RRpSRK in which pS is phospho-serine corresponding to amino acid 7 of human CENP-A (centromere protein A) 详细描述见链接：http://www.millipore.com/catalogue/item/04-792