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保存条件 ：Sealed in dry,2-8°C
保质期 ：详见产品说明
英文名 ：Ginsenoside Rb3
库存 ：999
供应商 ：仕诺达生物
CAS号 ：68406-26-8
规格 ：20mg（多规格可选）
简介：
（1）人参皂甙 Rb3是一种从人参中提取的天然有效成分。它是由一种类似皂草苷的化合物组成，具有许多药理活性。
（2）人参皂甙 Rb3具有多种生理活性，包括抗氧化、抗炎、抗肿瘤、抗衰老等作用。它还可以提高免疫力、调节血糖、改善记忆力和促进心血管健康等。
（3）人参皂甙 Rb3的制法一般是通过从人参中提取和纯化得到。具体的制法包括溶剂萃取、分离、结晶和干燥等步骤
| 中文名 | 人参皂甙 Rb3 |
| 英文名 | ginsenoside rb3 |
| 别名 | 红茶浸膏粉 人参皂苷Rb3 人参皂荚RB2 人参皂甙 Rb3 人参皂甙 RB3 人参皂苷 Rb3 人参皂苷RB3对照品, 人参皂苷RB3(标准品) 人参皂苷RB3(人参皂荚RB2 人参皂苷 RB3, 来源于人参 GINSENOSIDE RB3 人参皂甙 RB3 |
| 英文别名 | Gypenoside IV xylopyranosyl- ginsenoside rb3 Ginsenoside Rb3 GINSENOSIDE Rb3(SH) hydroxydammar-24-en-20-yl6-O-β-D- β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D- glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl6-o-beta-d-xylopyranosyl- [3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-12β-hydroxy-5α-dammar-24-en-20-yl]6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside alpha-D-Glucopyranoside, (3-beta,12-beta)-3-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-xylopyranosyl- (1R,4E)-1-{(8xi,9xi,12α,13xi,14β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxy-4,4,10,14-tetramethylgonan-17-yl}-1,5-dimethylhept-4-en-1-yl 6-O-β-D-xylopyranosyl-β-D-allopyranoside |
| CAS | 68406-26-8 |
| 化学式 | C53H90O22 |
| 分子量 | 1079.27 |
| InChI | InChI=1/C53H90O22/c1-8-23(2)10-9-15-53(7,75-48-44(67)40(63)38(61)31(72-48)22-69-46-42(65)35(58)28(57)21-68-46)25-13-16-52(6)24-11-12-32-50(3,4)33(14-17-51(32,5)26(24)18-27(56)34(25)52)73-49-45(41(64)37(60)30(20-55)71-49)74-47-43(66)39(62)36(59)29(19-54)70-47/h10,24-49,54-67H,8-9,11-22H2,1-7H3/b23-10+/t24?,25?,26?,27-,28+,29+,30+,31+,32?,33?,34?,35-,36+,37+,38+,39-,40+,41-,42+,43+,44+,45+,46-,47-,48-,49-,51+,52+,53+/m0/s1 |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 熔点 | 193～195℃ |
| 沸点 | 1117.1±65.0 °C(Predicted) |
| 比旋光度 | (c, 1 in MeOH)+19.4 |
| 闪点 | 634.2°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) 、吡啶 (微溶) |
| 折射率 | 1.621 |
| 酸度系数 | 12.85±0.70(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 稳定性 | 吸湿性 |
| 敏感性 | Easily absorbing moisture |
| 外观 | 整洁 |
| 颜色 | White |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参，绞股蓝。 |
| MDL号 | MFCD10566396 |
| 体外研究 | Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC 50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL). Ginsenoside Rb3 (0.1-10 μM) significantly increases cell viability and inhibits lactate dehydrogenase (LDH) release in a dose-dependent manner. PC12 cell viability as determined by MTT reduction is also markedly decreased after the cell is exposed to oxygen and glucose deprivation (OGD)/OGD-Rep. But, when the cells are pretreated with Ginsenoside Rb3 (0.1, 1, and 10 μM), OGD/OGD-Rep induced cell toxicity is significantly attenuated, which is concentration-dependently attenuated by Ginsenoside Rb3 treatment. The viabilities are raised to 52.8%±5.6%, 64.6%±5.7%, and 76.4%±8.8%, respectively, compared with the control group. |
| 体内研究 | Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc Min/+ mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments. |
计算化学数据：
- 分子量：1079.2685g/mol
- 化合物是否规范：True
- 疏水参数计算参考值（XLogP3-AA）：0.4
- 准确质量：1078.59237449
- 同位素质量：1078.59237449
- 复杂度：1920
- 可旋转化学键数量：16
- 氢键供体数量：14
- 氢键受体计数：22
- 拓扑极表面积：357
- 重原子数量：75
- 确定原子立构中心数量：23
- 不确定原子立构中心数量：6
- 确定化学键立构中心数量：1
- 不确定化学键立构中心数量：0
- 同位素原子计数：0
- 共价键单元数量：1
- CACTVS Substructure Key Fingerprint：AAADcfB8PgAAAAAAAAAAAAAAAAAAAYAAAAA0aNEiAAAAAGDAAAAAGgAACAAAD1SwgAMCCAAABgCAAiBCAAAAAAAgAAAACAAAAAgREAIAAQAiQAAFgAAPAAPA4PwPgAAAAAAAAADAAAYAADAAAQAACAAAAA==
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