N-Oleoylethanolamine/N-Oleoylethanolamine/N-Oleoylethanolamine

保存条件 ：对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

保质期 ：根据订购时间与产品批次判定

英文名 ：N-油酰基ethanolamine-N-Oleoylethanolamine

库存 ：N-油酰基ethanolamine-N-Oleoylethanolamine

供应商 ：艾美捷

CAS号 ：N-油酰基ethanolamine-N-Oleoylethanolamine

规格 ：100mg

产品名称：N-油酰基ethanolamine-N-Oleoylethanolamine

产品货号：1751-100

产品规格：100mg

背景资料：固体

保存建议：N-油酰基ethanolamine-N-Oleoylethanolamine对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：N-Oleoylethanolamine is a naturally occurring acylethanolamide that has been shown to have many biological functions. N-Oleoylethanolamine has been shown to be an efficacious inhibitor of acid ceramidase as well as an inhibitor of glucosylation of natural ceramides.1 It is specifically an inhibitor of the acid ceramidase found in human kidney and cerebellum with an IC50 of approximately 500μM. Farber’s disease is characterized by a lack of acid ceramidase activity and N-oleoylethanolamine can be used to study aspects of this disease. Whereas the inhibitor D-MAPP potently inhibits alkaline ceramidase (IC50 approximately 5μM) N-oleoylethanolamine shows only slight inhibitory characteristics towards this ceramidase.2 N-Oleoylethanolamine is chemically related to the endocannabinoid anandamide, although it is not a cannabinoid itself. It is produced, during feeding, in the small-intestinal enterocytes from oleic acid and phosphatidylethanolamine and acts as a satiety signal (by engaging peroxisome proliferator-activated receptors) and alters gastrointestinal motility. The levels of N-oleoylethanolamine are low during food deprivation (which activates a hunger signal) and normalize with food intake (which activates a satiety, but not a satiation, signal through sensory afferent neurons). It has been shown to reduce weight gain in rats and mice and has been suggested as a tool to combat obesity, diabetes, and eating disorders.3 N-Oleoylethanolamine is also released during sleep deprivation and it is thought that it may act as an endogenous neuroprotective signal.4 Other functions of N-oleoylethanolamine include altering peripheral lipid metabolism, inhibiting gastric emptying, inhibiting insulin metabolic and mitogenic signaling, enhancing memory consolidation, and altering stress responses.

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关键词：生化试剂，N-油酰基ethanolamine，待更新