PeproTech重组人Gremlin-1 10ug

价格：询价

品牌：PEPROTECH 品牌认证

货号：120-42

产品详情

Recombinant Human Gremlin-1

产品编号:

120-42

别名:

CKTSF1B1, DAND2, DRM, IHG-2

描述:

Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.

氨基酸序列:

KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD

来源:

CHO cells

纯度:

Greater than 90% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED₅₀for this effect is 0.07-0.11 μg/ml.

原产国:

USA

仅用于研究。不适用于诊断或治疗。