IL 29 Protein (GWB-10CE5B)

保存条件 ：Lyophilized IFN-Lambda 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution IFN-Lambda 1 Recombinant should be stored at 4C between 2-7 days and for future use below -18 C.For long term storage it

供应商 ：genway

抗体英文名 ：IL 29 Protein (GWB-10CE5B)

Sequence: GPVPTSKPTTTGKGCHIGRFKSLSPQ E L A SFKK A RD A L E E SLKLKNWSCSSPVFPGNWDLRLLQVR E RPV A L E A E L A LTLKVL E A A A GP A L E DVLDQPLHTLHHILSQLQ A CIQPQPT A GPRPRGRLHHWLHRLQ E A PKK E S A GCL E A SVTFNLFRLLTRDLKYV A DGNLCLRTSTHP E ST.

Solubility: It is recommended to reconstitute the lyophilized IL-29 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Introduction IL-29 is distantly related to type I interferons and the IL-10 family. Expression of IL-29 is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-29 exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity.IL-29 acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda3 are closely positioned genes on human chromosome 19.IL-29 induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-29 is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-29 produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection. IFN-Lambda 1 antiviral and antiproliferative activity requires Interferon-Lambda 2 receptor tyrosine residues.Description IL-29 human recombinant produced in E.Coli ?is a single, non-glycosylated, polypeptide chain containing 181 amino acids and having a molecular mass of 20 kDa.