机制研究的利器：RNA-seq机制研究套餐

提供商 ：吉凯基因

服务名称 ：蛋白组学

机制研究的利器：RNA-seq机制研究套餐
（省心、省力、省时、省钱）
且看RNA-seq+IPA高级生信分析这对神雕侠女是如何轻松搞定机制研究
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您只需要提供idea，后续机制研究交给吉凯

RNA-seq机制研究套餐采用了更高级的生信分析数据库Ingenuity Pathway Analysis（IPA）来对测序数据进行分析，IPA所基于的后台是一个高度结构化的ingenuity knowledge base数据库，并且它是一个收费数据库，每年的账号使用费数十万，该数据库经历20年的海量知识数据投入，号称拥有近500名PhD对近700多种权威杂志进行全文阅读，3000多种杂志进行摘要阅读，保存每周更新一次。目前数据库存储了530万条以上的生物实验发现，150万条互作信息和3万种以上的分子信息；此外，还构建了完整的功能疾病分类数据库，绘制了800种以上的信号通路，代谢通路等，为广大科研工作者提供及时、准确的生物信息学数据支持。

吉凯基因IPA分析主要包含5个模块：
经典通路分析      上游调控分析    疾病和功能分析     调控效应分析    互作网路分析





RNA-seq+IPA分析应用文献集锦

1. Reperfusion-triggered stress protein response in the myocardium is blocked by post-conditioning. Systems biology pathway analysis highlights the key role of the canonical aryl-hydrocarbon receptor pathway  IF=23.239
2. Low-Molecular-Weight Protein Tyrosine Phosphatase Predicts Prostate Cancer Outcome by Increasing the Metastatic Potential  IF=17.298
3. Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia IF=16.562
4. The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves  IF=14.11
5. Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity  IF=12.28
6. Kidney-targeted inhibition of protein kinase C-a ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction  IF=8.306
7. LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression  IF=10.698
8. Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis IF=10.698
9. Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination IF=9.58
10. In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage IF=9.02
11. An FGFR3 autocrine loop sustains acquired resistance to trastuzumab in gastric cancer patients IF=8.91
12. Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis IF=8.731
13. Epigenetic modification of microRNA-200b contributes to diabetic vasculopathy IF=8.402
14. Identification of transcriptome signature for myocardial reductive stress  IF=7.79
15. Transcriptomic and Functional Analyses on the Effects of Dioxin on Insulin Secretion of Pancreatic Islets and #-cells  IF=7.14
16. Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development  IF=6.77
17. Essential role of JunD in cell proliferation is mediated via MYC signaling in prostate cancer cells  IF=6.5
18. Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1- dependent gene expression by Epstein-Barr virus latent membrane protein 1 IF=6.46
19. RGS4 maintains chronic pain symptoms in rodent models IF=6.07
20. PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ ATF4 signaling pathway in pancreatic adenocarcinoma cells IF=5.95
21. Lamin A/C negatively regulated by miR‐124‐3p modulates apoptosis of vascular smooth muscle cells during cyclic stretch application in rats  IF=5.86
22. PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water IF=5.714
23. Gene Expression Profiling of NFATc1-Knockdown in RAW 264.7 Cells: An Alternative Pathway for Macrophage Differentiation IF=5.656
24. Differential Regulation of TLE3 in Sertoli Cells of the Testes during Postnatal Development  IF=5.656
25. Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways IF=5.515
26. Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery  IF=5.39
27. Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage IF=4.18
28. Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy IF=3.545
29. IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα− BCa and AR− PCa cells and promotes cell survival  IF=2.933
30. Identification of the inhibitor of growth protein 4 (ING4) as a potential target in prostate cancer therapy IF=2.884