重组人血管紧张素转化酶2(＞95%)北京品牌

库存 ：345

英文名 ：Recombinant Human ACE-2 (C-Fc)

保质期 ：6个月

供应商 ：北京百奥莱博科技有限公司

保存条件 ：-20℃

规格 ：10μg|50μg|500μg|1mg

特别提示：包括重组人血管紧张素转化酶2在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人血管紧张素转化酶2
英文名称：Recombinant Human ACE-2 (C-Fc)
产品货号：JN2061
产品规格：10μg|50μg|500μg|1mg

Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.

制剂：Lyophilized from a 0.2μm filtered solution of 20mM Tris-HCl,300mM NaCl,1mM ZnCl2,10% Glycerol,pH7.4.
纯度：＞95% as determined by reducing SDS-PAGE.
内毒素：＜0.1ng/μg (1 EU/μg) as determined by LAL test.
生物活性：

Immobilized Human ACE-2(Fc Tag)(Cat#JN2061) at 10μg/ml (100μl/well) can bind SARS-CoV-2 S Protein RBD-SD1-mFc(Cat#JN2088).The ED₅₀of Recombinant SARS-CoV-2 S Protein RBD-mFc(Cat#JN2088) is 15.5ng/ml。

保存条件：-20℃，有效期6个月，避免反复冻融。

背景资料：
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family,the ACE family includes somatic and germinal ACE.ACE-2 cleaves angiotensins I and II as a carboxypeptidase,ACE-2 converts angiotensin I to angiotensin 1-9,and angiotensin II to angiotensin 1-7.ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency.ACE-2 can be high expressed in testis,kidney and heart,in colon,small intestine and ovary at moderate levels.Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity.ACE-2 may play an important role in regulating the heart function.

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