α-Melanocyte-Stimulating Hormone (MSH), amide/581-05-5/刘经理18751911884微信同号

CAS号 ：581-05-5

α-Melanocyte-Stimulating Hormone (MSH), amide 581-05-5Description α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. 
 
IC50 & Target Melanocortin 1 receptor[1]
Adenylyl cyclase[1]
 
In Vitro α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2].
 
In Vivo α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2].
 
Molecular Weight 1664.88 
 
Formula C₇₇H₁₀₉N₂₁O₁₉S
 
CAS No. 581-05-5
 
Sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
 
Sequence Shortening Ac-SYSMEHFRWGKPV-NH2
 


 Description α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. 
 
IC50 & Target Melanocortin 1 receptor[1]
Adenylyl cyclase[1]
 
In Vitro α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2].
 
In Vivo α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2].
 
Molecular Weight 1664.88 
 
Formula C₇₇H₁₀₉N₂₁O₁₉S
 
CAS No. 581-05-5
 
Sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
 
Sequence Shortening Ac-SYSMEHFRWGKPV-NH2
 
Shipping Room temperature in continental US; may vary elsewhere.
 
Storage Powder  -80°C 2 years 
  -20°C 1 year 
In solvent -80°C 6 months 
  -20°C 1 month 
 
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