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保存条件 :Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
库存 :货期:1-2天
供应商 :MedChemExpress LLC
规格 :10 mM * 1 mL/50 mg/100 mg/5 mg/10 mg
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MMP-9-IN-1
CAS No. : 502887-71-0
MCE 国际站:MMP-9-IN-1
产品活性:MMP-9-IN-1 是一种特异性的基质金属蛋白酶-9 (MMP-9) 抑制剂,选择性靶向 MMP-9 的血红素 (PEX) 域,但不作用于其他 MMP。
研究领域:Metabolic Enzyme/Protease
作用靶点:MMP
In Vitro: MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity.
MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells.
In Vivo: MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.
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