HIF2A / EPAS1 Antibody

保存条件 ：Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

库存 ：100

宿主 ：Rabbit

靶点 ：Mouse (97%), Chicken (94%), Pig (99%), Rat (95%), Xenopus laevis (86%), Bovine (98%), Xenopus tropicalis (86%)

抗体名 ：BHLHE73, HIF2A, MOP2, PASD2

规格 ：50 μl

分子量：
96kDa
细胞定位：
Antigen Cellular Localization:Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Tian H.,et al.Genes Dev. 11:72-82(1997).Hogenesch J.B.,et al.J. Biol. Chem. 272:8581-8593(1997).Ema M.,et al.EMBO J. 18:1905-1914(1999).Furlow P.W.,et al.J. Biol. Chem. 284:9050-9058(2009).Percy M.J.,et al.Blood 111:5400-5402(2008).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality HIF2A / EPAS1 antibody.
功能：
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
总结：
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
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