GPR183 / EBI2 Antibody (Extracellular Domain)

保存条件 ：Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

库存 ：100

宿主 ：Rabbit

靶点 ：Human GPR183 / EBI2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NBEA (39%).

抗体名 ：EBI2

规格 ：50 μg

分子量：
41kDa
细胞定位：
Antigen Cellular Localization:Cell membrane; Multi-pass membrane protein
形式：
Liquid
参考文献：
Birkenbach M.P.,et al.J. Virol. 67:2209-2220(1993).Ota T.,et al.Nat. Genet. 36:40-45(2004).Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.Dunham A.,et al.Nature 428:522-528(2004).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality GPR183 / EBI2 antibody (Extracellular Domain).
功能：
Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
总结：
Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
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