PHAR4 Antibody (C-term) [AMM07135G]

靶点 ：Phosphatase and actin regulator 4, PHACTR4

浓度 ：Affinity Purification

应用范围 ：WB

宿主 ：Rabbit

适应物种 ：H

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

克隆性 ：Polyclonal

保存条件 ：Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

形态 ：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原 ：This PHAR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PHAR4.

规格 ：400 µl/200 µl/100 µl/50 µl

分子量：78211

细胞定位：Cytoplasm. Cell projection, lamellipodium

功能：Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

稀释方法：WB--1:1000