Phospho-STAT5a(S726) Antibody

亚型 ：Rabbit Ig

保存条件 ：Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

库存 ：100

宿主 ：Rabbit

靶点 ：This STAT5a Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S726 of human STAT5a.

抗体名 ：STAT5

规格 ：100 μl

分子量：
90647 Da
细胞定位：
Antigen Cellular Localization:Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
形式：
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献：
Martens, N., et al., J. Biol. Chem. 280(14):13817-13823 (2005).Defilippi, P., et al., J. Cell Biol. 168(7):1099-1108 (2005).Sekine, Y., et al., J. Biol. Chem. 280(9):8188-8196 (2005).Sultan, A.S., et al., Oncogene 24(5):746-760 (2005).Moriggl, R., et al., Cancer Cell 7(1):87-99 (2005).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Phospho-STAT5a(S726) antibody.
功能：
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
总结：
STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.
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