H6PD Antibody (C-term) [APG02911G]

靶点 ：GDH/6PGL endoplasmic bifunctional protein, Glucose 1-dehydrogenase, Hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase, 6PGL, H6PD, GDH

浓度 ：Affinity Purification

应用范围 ：WB, IHC-P

宿主 ：Rabbit

适应物种 ：H, M

保质期 ：1-2年

供应商 ：安诺伦（北京）生物科技有限公司

克隆性 ：Polyclonal

保存条件 ：Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

形态 ：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原 ：This H6PD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 743-769 amino acids from the C-terminal region of human H6PD.

规格 ：400 µl/200 µl/100 µl/50 µl

分子量：88893

细胞定位：Endoplasmic reticulum lumen

功能：Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520).

总结：Tissue Location:Present in most tissues examined, strongest in liver.

稀释方法：WB--1:1000IHC-P--1:100~500