SCARF1 Antibody

保存条件 ：Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

克隆性 ：单克隆

适应物种 ：Human

库存 ：100

宿主 ：Rabbit

应用范围 ：WB, IHC

靶点 ：A synthetic peptide corresponding to residues in human SCARF1 was used as an immunogen.

抗体名 ：KIAA0149, SREC

规格 ：100 μl

分子量：
87387 Da
细胞定位：
Antigen Cellular Localization:Membrane; Single-pass type I membrane protein
形式：
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：
1. Hideki Adachi, et al. The Journal of Biological Chemistry, 277:24014-24021, 2002 2. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008)
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality SCARF1 antibody.
功能：
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).
总结：
Scavenger receptor class F member 1 (SCARF1) mediates the selective uptake of modified low density lipoprotein (LDL), such as acetylated LDL and oxidized LDL, into endothelial cells (1). It also mediates heterophilic interactions, suggesting that it functions as an adhesion protein (2). SCARF1 has several characteristic domain structures; an N-terminal extracellular domain with seven epidermal growth factor (EGF)-like cysteine pattern signatures, and an unusually long C-terminal cytoplasmic domain composed of a Ser/Pro-rich region followed by a Gly-rich region. SCARF1 is expressed at high levels in endothelial cells but not in smooth muscle cells (1).
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