Human TIM-3 / HAVCR2 (22-142) Protein, Fc Tag

英文名 ：Human TIM-3 / HAVCR2 (22-142) Protein, Fc Tag

库存 ：In Stock

供应商 ：ACROBiosystems

规格 ：1mg

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>97% as determined by SDS-PAGE.

活性:


产品背景:
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

产品描述:
Human TIM-3 (22-142), Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 42 kDa. The predicted N-terminus is Ser 22. The reducing (R) protein migrates as 45 kDa in SDS-PAGE due to glycosylation.