低密度脂蛋白受体相关蛋白5+6抗体

供应商 ：江西江蓝纯生物试剂有限公司

库存 ：189

克隆性 ：单克隆

保质期 ：1年

抗体英文名 ：LRP5 + LRP6

抗体名 ：低密度脂蛋白受体相关蛋白5+6抗体

适应物种 ：人/动物/植物

应用范围 ：WB,ELISA等

浓度 ：1mg/ml

保存条件 ：-20 °

规格 ：100ul/200ul

产品货号 :  jlcR18366
英文名称 :  LRP5 + LRP6
中文名称 : 低密度脂蛋白受体相关蛋白5+6抗体
别    名 :  BMND 1; BMND1; EVR 1; EVR 4; EVR1; EVR4; FLJ90062; FLJ90421; HBM; LDL Receptor Related Protein 5 + 6; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 5 precursor; Low density lipoprotein receptor related protein 6; Low density lipoprotein receptor related protein 6 precursor; LR 3; LR3; LRP 5; LRP 6; LRP 7; LRP7; OPPG; OPS; OPTA 1; OPTA1; VBCH 2; VBCH2.  
研究领域 :  肿瘤  细胞生物  神经生物学  信号转导  细胞膜受体  细胞膜蛋白  
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应 :  Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 :  176kDa
细胞定位 :  细胞膜
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免 疫 原 :  KLH conjugated synthetic peptide derived from human LRP5 + LRP6:521-620/1615
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍 :   LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

Subcellular Location:
Membrane; single-pass type I membrane protein

Similarity:
Belongs to the LDLR family.
Contains 4 EGF-like domains.
Contains 3 LDL-receptor class A domains.
Contains 20 LDL-receptor class B repeats.

SWISS:
O75197

Gene ID:
4040
4041

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.