信号转导衔接结合蛋白抗体

供应商 ：江西江蓝纯生物试剂有限公司

库存 ：66

克隆性 ：单克隆

保质期 ：1年

抗体英文名 ：AMSH

抗体名 ：信号转导衔接结合蛋白抗体

适应物种 ：人/动物/植物

应用范围 ：WB,ELISA等

浓度 ：1mg/ml

保存条件 ：-20 °

规格 ：100ul/200ul

产品货号 :  jlcR7735
英文名称 :  AMSH
中文名称 :  信号转导衔接结合蛋白抗体
别    名 :  Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; STABP_HUMAN; STAM binding protein; STAM-binding protein; STAMBP.  
研究领域 :  细胞生物  细胞周期蛋白  结合蛋白  表观遗传学  
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应  :  Human, Mouse, Rat, Dog, Horse, Rabbit,
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 :  47kDa
细胞定位 :  细胞核 细胞浆 细胞膜
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免 疫 原 :  KLH conjugated synthetic peptide derived from human AMSH:331-420/424
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍 :   Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.

Function:
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.

Subcellular Location:
Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated after BMP type I receptor activation.
Ubiquitinated by SMURF2 in the presence of RNF11.

Similarity:
Belongs to the peptidase M67C family.
Contains 1 MPN (JAB/Mov34) domain.

SWISS:
O95630

Gene ID:
10617

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片