糖尿病相关同源结构域蛋白SIX5抗体价格

供应商：江西江蓝纯生物试剂有限公司

库存：194

克隆性：单克隆

保质期：1年

抗体英文名：SIX5

抗体名：糖尿病相关同源结构域蛋白SIX5抗体

适应物种：人/动物/植物

应用范围：WB,ELISA等

浓度：1mg/ml

保存条件：-20 °

规格：100ul/200ul

产品货号 :  jlcR17505
英文名称 :  SIX5
中文名称 :  糖尿病相关同源结构域蛋白SIX5抗体
别    名 :  BOR2; DM locus associated homeodomain protein; DM locus-associated homeodomain protein; DMAHP; Dystrophia myotonica associated homeodomain protein; Homeobox protein SIX5; Sine oculis homeobox homolog 5; sine oculis related homeobox 5 homolog (Drosophila); SIX homeobox 5; SIX5; SIX5_HUMAN.
研究领域 :  细胞生物发育生物学糖尿病表观遗传学
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应 :  Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 :  75kDa
细胞定位 :  细胞核细胞浆
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免疫原 :  KLH conjugated synthetic peptide derived from human SIX5:221-320/739
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储存液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍 :  The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]

Function:
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera.

DISEASE:
Defects in SIX5 are the cause of branchiootorenal syndrome type 2 (BOR2) [MIM:610896]. BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable.

Similarity:
Belongs to the SIX/Sine oculis homeobox family.
Contains 1 homeobox DNA-binding domain.

SWISS:
Q8N196

Gene ID:
147912

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.