RBAP46/RBAP48 (D4F8) Rabbit mAb价格_品牌:Cell Signaling Technology-丁香通官网

抗体英文名：RBAP46/RBAP48 (D4F8) Rabbit mAb

抗原：synthetic peptide corresponding to residues near the amino terminus of human RBAP48 protein

应用范围：W

供应商：CST

库存：大量

级别：详见MSDS文件

适应物种：H,M,R,Mk,Hm,C,GP

保质期：详见说明书

是否单克隆：1

保存条件：-20°c

规格：100 ul (10 western blots)/carrier free & custom formulation / quantity

pathway more info application references datasheet PDF MSDS PDF protocols

Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Hm=Hamster Mk=Monkey C=Chicken GP=Guinea Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk (Hm) (C) (GP)	Endogenous	48	Rabbit IgG

Protocols	9067: Western Blotting
Specificity / Sensitivity	RBAP46/RBAP48 (D4F8) Rabbit mAb recognizes endogenous levels of total RBAP46 and RBAP48 proteins.
Source / Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human RBAP48 protein. Western Blotting Western blot analysis of extracts from various cell lines using RBAP46/RBAP48 (D4F8) Rabbit mAb.
Background	Retinoblastoma-associated proteins 46 and 48 (RBAP46 and RBAP48; also known as RBBP7 and RBBP4) were first characterized in human cells as proteins that bind to the retinoblastoma (Rb) tumor suppressor protein (1). Since then, these proteins have been shown to be components of many protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF-1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin assembly during DNA replication (2,3). RBAP46 and RBAP48 are also found in the nucleosome remodeling factor complex NURF, the nucleosome remodeling and histone de-acetylation complex NuRD, and the Sin3/HDAC histone de-acetylation complex (4-7). More recently, RBAP46 and RBAP48 were identified as components of the polycomb repressor complex PRC2, which also contains EED and Ezh2 (8). RBAP46 and RBAP48 bind to the histone fold region of histone H4 and are believed to target these chromatin remodeling, histone acetylation, and histone de-acetylation complexes to their histone substrates (3). Qian, Y.W. et al. (1993) Nature 364, 648-52. Verreault, A. et al. (1996) Cell 87, 95-104. Verreault, A. et al. (1998) Curr Biol 8, 96-108. Barak, O. et al. (2003) EMBO J 22, 6089-100. Zhang, Y. et al. (1999) Genes Dev 13, 1924-35. Zhang, Y. et al. (1997) Cell 89, 357-64. Kuzmichev, A. et al. (2002) Genes Dev 16, 2893-905. Cao, R. et al. (2002) Science 298, 1039-43.
Application References	Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
Companion Products	6882 RBAP46 (V415) Antibody 4241 CHD3 Antibody 4245 CHD4 Antibody 5356 HDAC1 (10E2) Mouse mAb 5113 HDAC2 (3F3) Mouse mAb 2540 HDAC2 Antibody 5647 MTA1 (D40D1) XP^® Rabbit mAb 5646 MTA1 (D17G10) Rabbit mAb 7071 Phototope^®-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody 7074 Anti-rabbit IgG, HRP-linked Antibody 7720 Prestained Protein Marker, Broad Range (Premixed Format) 7727 Biotinylated Protein Ladder Detection Pack 7003 20X LumiGLO^® Reagent and 20X Peroxide 9998 BSA 9999 Nonfat Dry Milk For Research Use Only. Not For Use In Diagnostic Procedures.