HEG同源蛋白1抗体

供应商 ：江西江蓝纯生物试剂有限公司

库存 ：57

克隆性 ：单克隆

保质期 ：1年

抗体英文名 ：HEG1

抗体名 ：HEG同源蛋白1抗体

适应物种 ：人/动物/植物

应用范围 ：WB,ELISA等

浓度 ：1mg/ml

保存条件 ：-20 °

规格 ：100ul/200ul

产品货号 :  jlcR15449
英文名称 :  HEG1
中文名称 :  HEG同源蛋白1抗体
别    名 :  HEG; HEG1; HEG1_HUMAN; KIAA1237; MST112; MSTP112; HEG homolog 1; Protein HEG homolog 
研究领域 :  心血管  细胞生物  免疫学  信号转导  
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应 :   Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 :  144kDa
细胞定位 :  细胞浆 细胞膜
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免 疫 原 :  KLH conjugated synthetic peptide derived from human HEG1:1151-1581/1381 <Extracellular>
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed

产品介绍 :   HEG1 (HEG homolog 1) is also known as HEG and is a 1,381 amino acid protein that exists as two alternatively spliced isoforms, one of which is a single-pass membrane protein and the other of which is secreted. HEG1, which is expressed in endothelial cells and smooth muscle cells of heart tissue, contains two EGF-like domains that play a role in calcium-binding events which may regulate concentric heart growth. The gene encoding HEG1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Function:
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions.

Subunit:
Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction.
Isoform 2: Secreted (Potential).

Similarity:
Contains 2 EGF-like domains.

SWISS:
Q9ULI3

Gene ID:
57493

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片