文献支持Human TNF-α High Sensitivity ELISA Kit（人肿瘤坏死因子α高敏 ELISA 试剂盒）

价格： ￥2650

品牌：MultiSciences 品牌认证

货号：70-EK182HS-96

产品详情

TNF 分子靶点信息概述

分子名：TNF, tumor necrosis factor
基因家族：Tumor necrosis factor superfamily
别名：TNFSF2; DIF; TNF-alpha
曾用名：TNFA
全称：TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)

TNF 分子靶点综述

TNF-α 为单核细胞、巨噬细胞、中性粒细胞、NK 细胞和 CD4+T 细胞产生的 17 kDa 细胞因子。它在免疫应答中具有多种调节功能，还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后，在全身循环，激活中性粒细胞，改变血管内皮细胞的特性，调控其它组织的代谢活性，以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α 在关节组织和其它组织发生炎症的发病机制具有重要作用。

人 Human TNF 分子靶点信息

分子名：TNF, tumor necrosis factor
别称：
- APC1 protein
- cachectin
- DIF
- TNF superfamily, member 2
- TNF-a
- TNF-alpha
- TNF, macrophage-derived
- TNF, monocyte-derived
- TNFA
- TNFSF2
- TNLG1F
- tumor necrosis factor alpha
- tumor necrosis factor ligand 1F
- tumor necrosis factor ligand superfamily member 2
- tumor necrosis factor-alpha
基因序列：NCBI_Gene: 7124
蛋白序列：UniProtKB: P01375

人 Human TNF靶点分子功能（预测）

Enables several functions, including identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Acts upstream of or within several processes, including regulation of cellular protein metabolic process; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular space; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).

该产品被引用文献

IF = 4.38 AEG-1 silencing attenuates M2-polarization of glioma-associated microglia/macrophages and sensitizes glioma cells to temozolomide. Scientific Reports (2021)
IF = 1.287 Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain:. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)
IF = 5.186 Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway. Frontiers in Cell and Developmental Biology (2020)
IF = 5.195 Sinomenine attenuated dextran sulfate sodium-induced inflammatory responses by promoting 14-3-3θ protein and inhibiting NF-κB signaling. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 3.411 Soluble B7-H5 Is a Novel Diagnostic, Severity, and Prognosis Marker in Acute Pancreatitis. Biomed Research International (2021)
IF = 8.469 Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patients. Cell Death & Disease (2021)
IF = 19.227 α-Synuclein induces Th17 differentiation and impairs the function and stability of Tregs by promoting RORC transcription in Parkinson's disease. BRAIN BEHAVIOR AND IMMUNITY (2022)
IF = 3.263 Anthocyanin ameliorates hypoxia and ischemia induced inflammation and apoptosis by increasing autophagic flux in SH-SY5Y cells. EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
IF = 6.53 Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 3.652 Hesperidin alleviates bupivacaine anesthesia-induced neurotoxicity in SH-SY5Y cells by regulating apoptosis and oxidative damage. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)
IF = 2.447 Knockdown of LINC01385 inhibits osteoarthritis progression by modulating the microRNA‑140‑3p/TLR4 axis. Experimental and Therapeutic Medicine (2021)
IF = 2.447 Knockdown of lncRNA NORAD inhibits the proliferation, inflammation and fibrosis of human mesangial cells under high‑glucose conditions by regulating the miR‑485/NRF1 axis. Experimental and Therapeutic Medicine (2021)
IF = 3.32 LncRNA H19 alleviates sepsis-induced acute lung injury by regulating the miR-107/TGFBR3 axis. BMC Pulmonary Medicine (2022)
IF = 2.447 Long non‑coding RNA HOTAIR knockdown alleviates lipopolysaccharide‑induced acute respiratory distress syndrome and the associated inflammatory response by modulating the microRNA‑30a‑5p/PDE7A axis. Experimental and Therapeutic Medicine (2021)
IF = 3.244 miR‐141‐3p inhibits vascular smooth muscle cell proliferation and migration via regulating Keap1/Nrf2/HO‐1 pathway. IUBMB LIFE (2020)
IF = 4.174 The protective effects of Agomelatine against Aβ1-42 oligomers-induced cellular senescence mediated by SIRT6 and Agomelatine’s potential in AD treatment. Human Cell (2021)
IF = 5.682 Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis. Aging-US (2021)
IF = 4.481 Effect of transcutaneous auricular vagus nerve stimulation on delayed neurocognitive recovery in elderly patients. AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)
IF = 6.1 A comparative study of the ameliorative effects of hyaluronic acid oligosaccharides and hyaluronic acid on DSS-induced colitis in mice and research on relevant mechanisms. Food & Function (2023)
IF = 2.466 GPNMB plays an active role in the M1/M2 balance. TISSUE & CELL (2021)
IF = 1.472 Antioxidant glutathione inhibits inflammation in synovial fibroblasts via PTEN/PI3K/AKT pathway: An in vitro study. Archives of Rheumatology (2021)
IF = 5.443 Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation. Stem Cells International (2019)
IF = 6.716 Distinct roles of programmed death ligand 1 alternative splicing isoforms in colorectal cancer. CANCER SCIENCE (2020)
IF = 2.892 Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo. CELL STRESS & CHAPERONES (2020)
IF = 5.834 GSK-3β/β-catenin pathway plays crucial roles in the regulation of NK cell cytotoxicity against myeloma cells. FASEB JOURNAL (2023)
IF = 2.6 Huoxue Jiedu Recipe represses mitochondrial fission to alleviate submandibular gland inflammation in Sjögren's syndrome. MICROBIOLOGY AND IMMUNOLOGY (2023)
IF = 1.871 Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells. Oncology Letters (2019)
IF = 2.261 Increased expression of BCL11B and its recruited chromatin remodeling factors during highly active antiretroviral therapy synergistically represses the transcription of human immunodeficiency virus type 1 and is associated with residual immune activation. ARCHIVES OF VIROLOGY (2019)
IF = 1.871 Inflammatory cytokine‑induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression. Oncology Letters (2019)
IF = 1.645 LncRNA XIST knockdown ameliorates oxidative low-density lipoprotein-induced endothelial cells injury by targeting miR-204-5p/TLR4. JOURNAL OF BIOSCIENCES (2020)
IF = 2.336 MiR‐29c protects against inflammation and apoptosis in Parkinson's disease model in vivo and in vitro by targeting SP1. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2019)
IF = 3.758 Monocytes Undergo Functional Reprogramming to Generate Immunosuppression through HIF-1α Signaling Pathway in the Late Phase of Sepsis. MEDIATORS OF INFLAMMATION (2020)
IF = 2.1 OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs. Molecular Medicine Reports (2020)
IF = 5.714 P-Hydroxylcinnamaldehyde induces tumor-associated macrophage polarization toward the M1 type by regulating the proteome and inhibits ESCC in vivo and in vitro. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 3.361 Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory responses. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 1.851 Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high‑glucose‑ and high‑insulin‑induced 3T3‑L1 adipocytes by promoting Nrf2 expression. Molecular Medicine Reports (2019)
IF = 4.084 RORγt inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL-17-producing Th17 and γδ-T cells in mice with ceruletide-induced pancreatitis. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2021)
IF = 3.269 Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro. Bioengineered (2022)
IF = 5.458 Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity. iScience (2021)
IF = 6.922 Tumor-Infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis. Journal of Inflammation Research (2022)
IF = 4.132 Weak UVB Irradiation Promotes Macrophage M2 Polarization and Stabilizes Atherosclerosis. Journal of Cardiovascular Translational Research (2021)
IF = 1.269 MicroRNA-181b stimulates inflammation via the nuclear factor-κB signaling pathway in vitro. Experimental and Therapeutic Medicine (2015)
IF = 4.369 A Cross-sectional Study Reveals a Chronic Low-grade Inflammation in Achalasia. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)
IF = 8.786 A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide.. Frontiers in Immunology (2022)
IF = 7.068 A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)
IF = 2.967 Accumulation of T‑helper 22 cells, interleukin‑22 and myeloid‑derived suppressor cells promotes gastric cancer progression in elderly patients. Oncology Letters (2018)
IF = 2.548 Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis:. Reproductive Sciences (2018)
IF = 1.277 Analgesic effect of TAK-242 on neuropathic pain in rats. International Journal of Clinical and Experimental Medicine (2015)
IF = 4.932 Anti-inflammatory activities of phospholipase C inhibitor U73122: Inhibition of monocyte-to-macrophage transformation and LPS-induced pro-inflammatory cytokine expression. INTERNATIONAL IMMUNOPHARMACOLOGY (2015)
IF = 0 Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling. BMC Complementary Medicine and Therapies (2021)
IF = 4.718 Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma. JOURNAL OF IMMUNOLOGY (2019)
IF = 2.73 Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2017)
IF = 3.244 Atorvastatin inhibits renal inflammatory response induced by calcium oxalate crystals via inhibiting the activation of TLR4/NF‐κB and NLRP3 inflammasome. IUBMB LIFE (2020)
IF = 3.659 Baicalein inhibits inflammatory response and promotes osteogenic activity in periodontal ligament cells challenged with lipopolysaccharides. BMC Complementary and Alternative Medicine (2021)
IF = 19.924 Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy. ADVANCED FUNCTIONAL MATERIALS (2022)
IF = 3.758 CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway. MEDIATORS OF INFLAMMATION (2020)
IF = 2.327 Changes in peripheral blood cytokines in patients with severe fever with thrombocytopenia syndrome. JOURNAL OF MEDICAL VIROLOGY (2021)
IF = 5.168 Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines. Oncotarget (2017)
IF = 3.659 Chimeric cytokine receptor enhancing PSMA-CAR-T cell-mediated prostate cancer regression. CANCER BIOLOGY & THERAPY (2020)
IF = 6.304 CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis. Cell Death & Disease (2020)
IF = 3.978 CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression. NEUROTOXICITY RESEARCH (2022)
IF = 10.211 Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer. JNCI-Journal of the National Cancer Institute (2019)
IF = 8.11 Construction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancer. OncoImmunology (2021)
IF = 6.359 Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition. Oncotarget (2015)
IF = 5.733 Decidua-derived granulocyte macrophage colony-stimulating factor induces polymorphonuclear myeloid-derived suppressor cells from circulating CD15+ neutrophils. HUMAN REPRODUCTION (2020)
IF = 4.06 Development of GPC3 and EGFR-dual-targeting chimeric antigen receptor-T cells for adoptive T cell therapy. American Journal of Translational Research (2021)
IF = 4.846 Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma. CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)
IF = 5.671 Development, characterisation, and in vitro anti-tumor effect of self-microemulsifying drug delivery system containing polyphyllin I. Drug Delivery and Translational Research (2022)
IF = 0.957 Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study. CHINESE MEDICAL JOURNAL (2016)
IF = 2.68 Dimethyl fumarate ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis through enhancing Nrf2 signaling. Toxicology Research (2022)
IF = 3.606 Downregulating lncRNA PRNCR1 ameliorates LPS-induced pulmonary vascular endothelial cell injury by modulating miR-330-5p/TLR4 axis. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)
IF = 4.174 Down-regulation of long non-coding RNA XIST aggravates sepsis-induced lung injury by regulating miR-16-5p. Human Cell (2021)
IF = 3.319 Downregulation of MALAT1 alleviates saturated fatty acid-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-κB axis. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2019)
IF = 3.998 Dynamic changes of innate lymphoid cells in acute ST-segment elevation myocardial infarction and its association with clinical outcomes. Scientific Reports (2020)
IF = 2.284 Effect of laser therapy on expression of angio- and fibrogenic factors, and cytokine concentrations during the healing process of human pressure ulcers. International Journal of Medical Sciences (2018)
IF = 3.246 Effect of Orthodontic Combined with Implant Repair on Aesthetic Effect and Gingival Crevicular Fluid Factor in Patients with Dentition Defect and Periodontitis. Biomed Research International (2022)
IF = 17.943 Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial. GUT (2019)
IF = 2.447 Effects of intranasal administration with Bacillus subtilis on immune cells in the nasal mucosa and tonsils of piglets. Experimental and Therapeutic Medicine (2018)
IF = 5.846 Effects of the Chinese herbal medicine Hong Huang decoction, on myocardial injury in breast cancer patients who underwent anthracycline-based chemotherapy. Frontiers in Cardiovascular Medicine (2022)
IF = 3.448 Effects of β2/aβ2 on oxLDL-induced CD36 activation in THP-1 macrophages. LIFE SCIENCES (2019)
IF = 18.187 Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial. Signal Transduction and Targeted Therapy (2022)
IF = 2.886 EGLIF-CAR-T Cells Secreting PD-1 Blocking Antibodies Significantly Mediate the Elimination of Gastric Cancer. Cancer Management and Research (2020)
IF = 3.534 Elevated Peripheral Frequencies of Th22 Cells: A Novel Potent Participant in Obesity and Type 2 Diabetes. PLoS One (2014)
IF = 3.612 Epithelial cell adhesion molecule promotes breast cancer resistance protein‐mediated multidrug resistance in breast cancer by inducing partial epithelial–mesenchymal transition. CELL BIOLOGY INTERNATIONAL (2021)
IF = 5.645 Evaluation of in vitro anti-acne activities of Ocimum basilicum L. water extract. INDUSTRIAL CROPS AND PRODUCTS (2022)
IF = 3.297 Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage. Annals of Translational Medicine (2020)
IF = 3.078 Expression of RANKL by peripheral neutrophils and its association with bone mineral density in COPD. RESPIROLOGY (2016)
IF = 3.984 Expression profile of PU.1 in CD4+T cells from patients with systemic lupus erythematosus. CLINICAL AND EXPERIMENTAL MEDICINE (2021)
IF = 2.027 Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB. Journal of Thoracic Disease (2019)
IF = 1.663 Fusobacterium nucleatum stimulates monocyte adhesion to and transmigration through endothelial cells. ARCHIVES OF ORAL BIOLOGY (2019)
IF = 4.932 GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 5.31 GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
IF = 4.546 Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination. Chinese Medicine (2023)
IF = 5.391 Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly. FASEB JOURNAL (2019)
IF = 4.96 GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI. BIOCHEMICAL PHARMACOLOGY (2020)
IF = 3.47 Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)
IF = 2.547 Helicobacter pylori tumor necrosis factor-α inducing protein promotes cytokine expression via nuclear factor-κB. WORLD JOURNAL OF GASTROENTEROLOGY (2013)
IF = 3.094 High Glucose-Induced Human Kidney Cell Apoptosis and Inflammatory Injury Are Alleviated by Circ_0008529 Knockdown via Circ_0008529-Mediated miR-485-5p/WNT2B Signaling. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)
IF = 3.758 hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro. MEDIATORS OF INFLAMMATION (2020)
IF = 2.833 Hugan Qingzhi medication ameliorates free fatty acid-induced L02 hepatocyte endoplasmic reticulum stress by regulating the activation of PKC-δ. BMC Complementary and Alternative Medicine (2020)
IF = 4.467 Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy. Cancer Biology & Medicine (2019)
IF = 3.525 Hydrofluoric acid and nitric acid cotreatment for biofunctionalization of polyetheretherketone in M2 macrophage polarization and osteogenesis. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)
IF = 2.884 Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-κB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes. INFLAMMATION (2018)
IF = 3.046 IFN-γ and TNF-α aggravate endothelial damage caused by CD123-targeted CAR T cell. OncoTargets and Therapy (2019)
IF = 10.793 IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)
IF = 4.054 Impaired myeloid-derived suppressor cells are associated with recurrent implantation failure: A case-control study. JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)
IF = 4.225 Increased antitumor activities of glypican-3-specific chimeric antigen receptor-modified T cells by coexpression of a soluble PD1–CH3 fusion protein. CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)
IF = 4.932 Increased Tim-3+ monocytes/macrophages are associated with disease severity in patients with IgA nephropathy. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 3.452 Infant immune response to hepatitis B vaccine after fetal exposure to telbivudine. Human Vaccines & Immunotherapeutics (2022)
IF = 4.157 Inflammatory Cytokines Changed in Patients With Depression Before and After Repetitive Transcranial Magnetic Stimulation Treatment. Frontiers in Psychiatry (2022)
IF = 4.927 Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process. MOLECULES (2022)
IF = 6.331 Influences of surface coating of PLGA nanoparticles on immune activation of macrophages. Journal of Materials Chemistry B (2018)
IF = 4.932 Inhibition of microRNA-92a ameliorates lipopolysaccharide-induced endothelial barrier dysfunction by targeting ITGA5 through the PI3K/Akt signaling pathway in human pulmonary microvascular endothelial cells. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 3.212 Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes. INFLAMMATION (2020)
IF = 3.143 Interleukin-21 Inhibits HBV Replication in vitro:. ANTIVIRAL THERAPY (2014)
IF = 3.361 Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 5.714 Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 4.4 Isobaric Tags for Relative and Absolute Quantitation (iTRAQ)-Based Proteomic Analysis of Hugan Qingzhi and Its Protective Properties against Free Fatty Acid-Induced L02 Hepatocyte Injury. Frontiers in Pharmacology (2017)
IF = 2.886 JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination. Cancer Management and Research (2020)
IF = 2.592 Levels of Interleukin-1β, Interleukin-18, and Tumor Necrosis Factor-α in Cerebrospinal Fluid of Aneurysmal Subarachnoid Hemorrhage Patients May Be Predictors of Early Brain Injury and Clinical Prognosis. World Neurosurgery (2017)
IF = 2.472 Lipopolysaccharide from biofilm-forming Pseudomonas aeruginosa PAO1 induces macrophage hyperinflammatory responses. JOURNAL OF MEDICAL MICROBIOLOGY (2021)
IF = 3.242 Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. JOURNAL OF DENTISTRY (2020)
IF = 2.1 lncRNA SNHG16 promotes the occurrence of osteoarthritis by sponging miR‑373‑3p. Molecular Medicine Reports (2020)
IF = 5.811 Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis.. Frontiers in Pharmacology (2021)
IF = 4.174 Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis. Human Cell (2022)
IF = 2.335 MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust Mites. Frontiers in Pediatrics (2018)
IF = 3.342 MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes. INFECTION GENETICS AND EVOLUTION (2022)
IF = 5.037 MicroRNA-92a serves as a risk factor in sepsis-induced ARDS and regulates apoptosis and cell migration in lipopolysaccharide-induced HPMEC and A549 cell injury. LIFE SCIENCES (2020)
IF = 4.096 MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway. MOLECULAR MEDICINE (2020)
IF = 4.565 miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. CELL CYCLE (2015)
IF = 6.684 MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis. Frontiers in Cell and Developmental Biology (2021)
IF = 3.024 MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.. European Review for Medical and Pharmacological Sciences (2020)
IF = 3.212 Modulating macrophage polarization on titanium implant surface by poly(dopamine)-assisted immobilization of IL4. Clinical Implant Dentistry and Related Research (2019)
IF = 4.966 Mycobacterial PPE13 activates inflammasome by interacting with the NATCH and LRR domains of NLRP3. FASEB JOURNAL (2020)
IF = 2.298 Myeloid-derived suppressor cell cytokine secretion as prognostic factor in myelodysplastic syndromes:. Innate Immunity (2020)
IF = 7.419 Nanobody-based CAR T cells targeting intracellular tumor antigens. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 6.51 Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)
IF = 4.932 NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 3.909 Nucleotide-binding oligomerization domain (NOD) plays an important role in neonatal infection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)
IF = 6.085 Oncolytic Vaccinia Virus Carrying Aphrocallistes vastus Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells. Marine Drugs (2022)
IF = 13.751 Original research: Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma. Journal for ImmunoTherapy of Cancer (2021)
IF = 4.078 Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state. CELLULAR IMMUNOLOGY (2020)
IF = 3.234 Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. LIFE SCIENCES (2018)
IF = 5.784 Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus. FREE RADICAL BIOLOGY AND MEDICINE (2016)
IF = 3.208 Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway. Drug Design Development and Therapy (2019)
IF = 4.24 Peptide WCPFSRSF ameliorates excitotoxicity and elevates synaptic plasticity in glutamate-damaged SH-SY5Y cells by modulating the PI3K/mTOR/EIF4E and BDNF/CREB/TrkB pathways. Food Bioscience (2022)
IF = 3.414 Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2019)
IF = 5.008 Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells. Oncotarget (2016)
IF = 5.64 Progesterone Suppresses Neisseria gonorrhoeae-Induced Inflammation Through Inhibition of NLRP3 Inflammasome Pathway in THP-1 Cells and Murine Models. Frontiers in Microbiology (2021)
IF = 3.654 Promotion of angiogenesis in vitro by Astragalus polysaccharide via activation of TLR4 signaling pathway. JOURNAL OF FOOD BIOCHEMISTRY (2022)
IF = 6.53 Protective effect of total Saponins from American ginseng against cigarette smoke-induced COPD in mice based on integrated metabolomics and network pharmacology. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 6.317 Protective mechanisms of Zanthoxylum Bungeanum essential oil on DSS-induced ulcerative colitis in mice based on colonic mucosal transcriptomic approach. Food & Function (2022)
IF = 6.291 Quantum dots bind nanosheet to promote nanomaterial stability and resist endotoxin-induced fibrosis and PM2.5-induced pneumonia. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)
IF = 5.293 RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus. Frontiers in Cellular and Infection Microbiology (2021)
IF = 4.218 Secretion of human soluble programmed cell death protein 1 by chimeric antigen receptor-modified T cells enhances anti-tumor efficacy. CYTOTHERAPY (2020)
IF = 9.188 Selective Targeting of Glioblastoma with EGFRvIII/EGFR Bitargeted Chimeric Antigen Receptor T CellEGFR/EGFRvIII Bitargeted CAR T Cells for Cancer Treatment. Cancer Immunology Research (2018)
IF = 2.592 Serum concentrations of TNF-α and its soluble receptors in Graves’ disease. Endocrine Connections (2020)
IF = 2.356 Short-term efficacy, safety and survival of laparoscopic radical resection for colorectal cancer patients with bowel obstruction. MEDICAL ENGINEERING & PHYSICS (2022)
IF = 6.388 Silibinin attenuated pseudo-allergic reactions and mast cell degranulation via PLCγ and PI3K/Akt signaling pathway. PHYTOTHERAPY RESEARCH (2023)
IF = 3.84 SNHG15 knockdown inhibits diabetic nephropathy progression in pediatric patients by regulating the miR-141/ICAM-1 axis in vitro. BIOSCIENCE REPORTS (2021)
IF = 2.127 Soluble CXCL16 promotes TNF-α-induced apoptosis in DLBCL via the AMAD10-NF-κB regulatory feedback loop. CELL BIOLOGY INTERNATIONAL (2019)
IF = 6.475 Structural characterization and anti-photoaging activity of a polysaccharide from Sargassum fusiforme. FOOD RESEARCH INTERNATIONAL (2022)
IF = 6.384 Syndecan‐4 involves in the pathogenesis of rheumatoid arthritis by regulating the inflammatory response and apoptosis of fibroblast‐like synoviocytes. JOURNAL OF CELLULAR PHYSIOLOGY (2019)
IF = 5.811 Systems Pharmacology Based Strategy for Q-Markers Discovery of HuangQin Decoction to Attenuate Intestinal Damage. Frontiers in Pharmacology (2018)
IF = 0.937 The Effect of Entecavir Therapy on Immune Status in Chronic Hepatitis B Patients.. Iranian Journal of Immunology (2019)
IF = 4.925 The nanomaterial-induced bystander effects reprogrammed macrophage immune function and metabolic profile. Nanotoxicology (2020)
IF = 8.786 The relationship between dyslipidemia and inflammation among adults in east coast China: A cross-sectional study. Frontiers in Immunology (2022)
IF = 5.195 Tomentosin suppressed M1 polarization via increasing MERTK activation mediated by regulation of GAS6. JOURNAL OF ETHNOPHARMACOLOGY (2023)
IF = 1.813 Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial. Evidence-based Complementary and Alternative Medicine (2020)
IF = 5.168 Treatment of hepatocellular carcinoma with a GPC3-targeted bispecific T cell engager. Oncotarget (2017)
IF = 3.659 Tumor associated neutrophils promote the metastasis of pancreatic ductal adenocarcinoma. CANCER BIOLOGY & THERAPY (2020)
IF = 2.849 Tumor Necrosis Factor-α Variations in Patients With Major Depressive Disorder Before and After Antidepressant Treatment. Frontiers in Psychiatry (2020)
IF = 3.633 Vitamin D deficiency is associated with thyroid autoimmunity: results from an epidemiological survey in Tianjin, China. ENDOCRINE (2021)
IF = 3.263 Vitexin protects against ethanol-induced liver injury through Sirt1/p53 signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
IF = 6.499 Volume kinetics of Ringer's lactate solution in acute inflammatory disease. BRITISH JOURNAL OF ANAESTHESIA (2018)
IF = 6.688 A Fusion Receptor as a Safety Switch, Detection, and Purification Biomarker for Adoptive Transferred T Cells. MOLECULAR THERAPY (2017)
IF = 3.69 Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways. JOURNAL OF ETHNOPHARMACOLOGY (2020)
IF = 3.361 CXCL16/CXCR6 axis promotes bleomycin-induced fibrotic process in MRC-5 cells via the PI3K/AKT/FOXO3a pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 22.553 Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis. IMMUNITY (2020)
IF = 4.631 Fibrinogen-Like Protein 1 as a Novel Biomarker of Psoriasis Severity. Journal of Inflammation Research (2022)
IF = 4.162 Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling. Drug Design Development and Therapy (2021)
IF = 2.07 Role of ascitic endocan levels in the diagnosis of spontaneous bacterial peritonitis in decompensated cirrhosis. BIOMARKERS (2020)
IF = 5.631 Role of CXCL16 in BLM-induced epithelial–mesenchymal transition in human A549 cells. RESPIRATORY RESEARCH (2021)
IF = 2.333 The phenotype of vascular smooth muscle cells co-cultured with endothelial cells is modulated by PDGFR-β/IQGAP1 signaling in LPS-induced intravascular injury. International Journal of Medical Sciences (2019)
IF = 2.447 Thioredoxin relieves lipopolysaccharide‑induced acute kidney injury in mice by reducing inflammation, oxidative stress and apoptosis. Experimental and Therapeutic Medicine (2021)
IF = 11.061 3D bioprinting of multi-cellular tumor microenvironment for prostate cancer metastasis. Biofabrication (2023)
IF = 6.376 4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes. MOLECULAR MEDICINE (2023)
IF = 3.861 Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1β-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-κB and MAPKs signaling pathways and inducing apoptosis. CYTOKINE (2022)
IF = 6.359 Adoptive immunotherapy using T lymphocytes redirected to glypican-3 for the treatment of lung squamous cell carcinoma. Oncotarget (2015)
IF = 3.138 C. butyricum lipoteichoic acid inhibits the inflammatory response and apoptosis in HT-29 cells induced by S. aureus lipoteichoic acid. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)
IF = 4.451 Chlorogenic acid improves intestinal barrier function by downregulating CD14 to inhibit the NF-κB signaling pathway. Journal of Functional Foods (2021)
IF = 7.129 Chronic exposure to microcystin-leucine-arginine induces epithelial hyperplasia and inflammation in the mouse bladder. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)
IF = 5.682 Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia. MOLECULAR NEUROBIOLOGY (2022)
IF = 2.846 Combined overexpression of four transcription factors promotes effector T cell dedifferentiation toward early phenotypes. IMMUNOGENETICS (2022)
IF = 6.684 Comprehensive Analysis of NAFLD and the Therapeutic Target Identified. Frontiers in Cell and Developmental Biology (2021)
IF = 4.927 Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway. MOLECULES (2023)
IF = 6.575 Consumption of Saturated Fatty Acids-Rich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR-γ. MOLECULAR NUTRITION & FOOD RESEARCH (2022)
IF = 16.874 Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis. Bioactive Materials (2022)
IF = 2.472 Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice. INTERNATIONAL IMMUNOPHARMACOLOGY (2015)
IF = 3.138 Different effects of lipoteichoic acid from C. butyricum and S. aureus on inflammatory responses of HT-29 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)
IF = 5.8 Discovery of a novel RIPK2 inhibitor for the treatment of inflammatory bowel disease. BIOCHEMICAL PHARMACOLOGY (2023)
IF = 2.63 Effects of Transcutaneous Electrical Acupoint Stimulation on Systemic Inflammatory Response Syndrome of Patients after Percutaneous Nephrolithotomy: A Randomized Controlled Trial. Evidence-based Complementary and Alternative Medicine (2021)
IF = 5.714 Eupalinolide B attenuates lipopolysaccharide-induced acute lung injury through inhibition of NF-κB and MAPKs signaling by targeting TAK1 protein. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 1.08 Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation. Molecular & Cellular Toxicology (2022)
IF = 3.144 Human bone marrow mesenchymal stem cells-derived exosomes protect against nerve injury via regulating immune microenvironment in neonatal hypoxic-ischemic brain damage model. IMMUNOBIOLOGY (2022)
IF = 2.744 Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)
IF = 8.593 Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma. Experimental Hematology & Oncology (2023)
IF = 2.493 Inhibition of TMUB1 blocks apoptosis and NF-κB pathway-mediated inflammation in recurrent spontaneous abortion. Immunity Inflammation and Disease (2023)
IF = 3.146 Interleukin 1β and tumor necrosis factor α promote hFOB1.19 cell viability via activating AP1. American Journal of Translational Research (2016)
IF = 3.654 Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway. JOURNAL OF FOOD BIOCHEMISTRY (2023)
IF = 4.932 Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 5.578 Long-Term Immunogenicity and In Vitro Prophylactic Protective Efficacy of M. tuberculosis Fusion Protein DR2 Combined with Liposomal Adjuvant DIMQ as a Boosting Vaccine for BCG. ACS Infectious Diseases (2023)
IF = 5.606 Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease. ARTHRITIS RESEARCH & THERAPY (2022)
IF = 2.189 Maslinic acid attenuates UVB-induced oxidative damage in HFF-1 cells. Journal of Cosmetic Dermatology (2023)
IF = 5.811 Metabolic and Network Pharmacological Analyses of the Therapeutic Effect of Grona styracifolia on Calcium Oxalate-Induced Renal Injury. Frontiers in Pharmacology (2021)
IF = 2.211 miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1. HUMAN IMMUNOLOGY (2022)
IF = 1.823 MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation. International Heart Journal (2022)
IF = 4.932 Morin hydrate inhibits atherosclerosis and LPS-induced endothelial cells inflammatory responses by modulating the NFκB signaling-mediated autophagy. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 2.043 Nesfatin-1 inhibits free fatty acid (FFA)-induced endothelial inflammation via Gfi1/NF-κB signaling. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)
IF = 7.419 Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota. BIOMEDICINE & PHARMACOTHERAPY (2023)
IF = 9.229 Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy. ACS Applied Materials & Interfaces (2021)
IF = 4.711 Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. MEDIATORS OF INFLAMMATION (2021)
IF = 2.37 Overexpression of TRIM3 protects against LPS-induced acute kidney injury via repressing IRF3 pathway and NLRP3 inflammasome. INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)
IF = 0 Oxymatrine blocks the NLRP3 inflammasome pathway, partly downregulating the inflammatory responses of M1 macrophages differentiated from THP-1 monocytes. Biochemistry and Biophysics Reports (2023)
IF = 5.714 Parthenolide alleviates microglia‐mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 3.149 Plasma biomarkers and delirium in critically ill patients after cardiac surgery: A prospective observational cohort study. HEART & LUNG (2023)
IF = 5.194 Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress. CHEMICO-BIOLOGICAL INTERACTIONS (2021)
IF = 4.932 Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 3.5 Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression. Journal of Dental Sciences (2023)
IF = 3.969 Progesterone-induced blocking factor-mediated Th1/Th2 balance correlates with fetal arrest in women who underwent in vitro fertilization and embryo transfer. CLINICAL IMMUNOLOGY (2021)
IF = 5.811 Puerarin Prevents Acute Liver Injury via Inhibiting Inflammatory Responses and ZEB2 Expression. Frontiers in Pharmacology (2021)
IF = 5.714 Quercetin protects endothelial function from inflammation induced by localized disturbed flow by inhibiting NRP2 -VEGFC complex. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 7.644 Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition. OncoImmunology (2016)
IF = 7.561 Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival In Vivo With Low Cytokines Release. Frontiers in Immunology (2021)
IF = 2.348 Regulation of CBL and ESR1 expression by microRNA-22‑3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)
IF = 2.485 Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective observational study. BMC EMERGENCY MEDICINE (2022)
IF = 5.31 Smoking increases oral mucosa susceptibility to Candida albicans infection via the Nrf2 pathway: In vitro and animal studies. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
IF = 4.803 The Natural Alkaloid (−)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1–TRAF6 Complex. JOURNAL OF NATURAL PRODUCTS (2023)
IF = 17.521 Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. Advanced Science (2022)
IF = 5.561 Ultra-High Hydrostatic Pressure Pretreatment on White Que Zui Tea: Chemical Constituents, Antioxidant, Cytoprotective, and Anti-Inflammatory Activities. Foods (2023)
IF = 9.756 Ultrasound-excited temozolomide sonosensitization induces necroptosis in glioblastoma. CANCER LETTERS (2022)
IF = 2.754 Analysis of Therapeutic Effect and Influencing Factors of Ultrasound-Guided Radiofrequency Ablation in the Treatment of Papillary Thyroid Microcarcinoma. JOURNAL OF ULTRASOUND IN MEDICINE (2023)

杭州联科生物技术股份有限公司

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入驻年限：13年

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背景介绍	肿瘤坏死因子α(TNF-α)也称为恶病质素和TNFSF1A，是一种脂肪因子，参与全身的炎症，同时也是刺激急性期反应的细胞因子之一。它主要由活化的巨噬细胞产生，也可由其它类型的细胞分泌，如CD4+淋巴细胞、NK细胞、中性粒细胞、肥大细胞、嗜酸性粒细胞和神经元等。它在免疫应答中具有多种调节功能，还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后，在全身循环，激活中性粒细胞，改变血管内皮细胞的特性，调控其它组织的代谢活性，以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α在关节组织和其它组织发生炎症的发病机制具有重要作用。最近，越来越多的信息表明TNF-α也参与了AIDS的发病机制。TNF-α的测定对于移植研究也非常有用。
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人TNF-α抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的TNF-α与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后，加入信号增强剂孵育，洗涤去除未结合的物质后，再次加入Streptavidin-HRP。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中TNF-α的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。
组分	包被抗TNF-α单克隆抗体的96孔聚苯乙烯酶标板人TNF-α冻干标准品 TNF-α检测抗体标准品稀释液辣根过氧化物酶标记的链霉亲和素信号增强剂浓缩液信号增强剂稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×)
分析类型	夹心ELISA
样本类型	血清、血浆，细胞培养上清及其他生物学样本
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
样本体积	血清血浆：20 μl 细胞培养上清：100μl
灵敏度	0.16pg/ml
标曲图
标准曲线范围	1.56-100pg/ml
回收率范围	100%-108%
平均回收率	1.04
板间变异系数	5.4 % - 7.0%
板内变异系数	4.1% -4.8 %