文献支持Human IL-1β High Sensitivity ELISA Kit（人白介素1β 高敏ELISA试剂盒）

价格： ￥3400

品牌：MultiSciences 品牌认证

货号：70-EK101BHS-96

产品详情

IL1B 分子靶点信息概述

分子名：IL1B, interleukin 1 beta
基因家族：Interleukins
别名：IL1F2; IL-1B; IL1-BETA

IL1B 分子靶点综述

白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1β是活化的巨噬细胞分泌的蛋白前体，通过caspase1(CASP1/ICE)水解产生的活化形式。该细胞因子是炎症反应的重要介导者，参与许多细胞活性，包括细胞增殖、分化和凋亡。IL-1是一类重要的蛋白家族，它们由生物活化的单核细胞所衍生，参与炎症反应和免疫应答。IL-1β表达升高会产生各种不同的自身炎症综合征，最显著的是单基因条件称为CAPS，是由于触发IL-1β加工的炎性体受体NLRP3发生突变而引起的。本试剂盒用来检测人IL-1β的成熟形式和未裂解的前体形式。

人 Human IL1B 分子靶点信息

分子名：IL1B, interleukin 1 beta
别称：
- catabolin
- IL-1
- IL-1 beta
- IL1-BETA
- IL1beta
- IL1F2
- interleukin 1, beta
- interleukin 1beta
- interleukin-1 beta
- preinterleukin 1 beta
- pro-interleukin-1-beta
基因序列：NCBI_Gene: 3553
蛋白序列：UniProtKB: P01584

人 Human IL1B靶点分子功能（预测）

Enables cytokine activity; integrin binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of nitrogen compound metabolic process; and regulation of signal transduction. Acts upstream of or within cellular response to organic substance and cellular response to xenobiotic stimulus. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bronchial disease (multiple); lung disease (multiple); and nose disease (multiple).

该产品被引用文献

IF = 4.481 Effect of transcutaneous auricular vagus nerve stimulation on delayed neurocognitive recovery in elderly patients. AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)
IF = 1.785 Brilliant blue G attenuates neuro‑inflammation via regulating MAPKs and NF‑κB signaling pathways in lipopolysaccharide‑induced BV2 microglia cells. Experimental and Therapeutic Medicine (2020)
IF = 3.946 Canonical and noncanonical pyroptosis are both activated in periodontal inflammation and bone resorption. JOURNAL OF PERIODONTAL RESEARCH (2022)
IF = 3.511 Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells. ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2023)
IF = 1.337 Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nuclear factor-κB pathway. World Journal of Clinical Cases (2021)
IF = 1.287 Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain:. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)
IF = 2.65 Iridoid from Eucommia ulmoides Oliv. Exerts Antiarthritis Effects by Inhibiting the JAK2/STAT3 Signaling Pathway In Vivo and In Vitro. Evidence-based Complementary and Alternative Medicine (2023)
IF = 5.186 Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway. Frontiers in Cell and Developmental Biology (2020)
IF = 5.195 Sinomenine attenuated dextran sulfate sodium-induced inflammatory responses by promoting 14-3-3θ protein and inhibiting NF-κB signaling. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 3.263 Anthocyanin ameliorates hypoxia and ischemia induced inflammation and apoptosis by increasing autophagic flux in SH-SY5Y cells. EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
IF = 6.53 Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 3.652 Hesperidin alleviates bupivacaine anesthesia-induced neurotoxicity in SH-SY5Y cells by regulating apoptosis and oxidative damage. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)
IF = 2.447 Knockdown of lncRNA NORAD inhibits the proliferation, inflammation and fibrosis of human mesangial cells under high‑glucose conditions by regulating the miR‑485/NRF1 axis. Experimental and Therapeutic Medicine (2021)
IF = 2.447 Long non‑coding RNA HOTAIR knockdown alleviates lipopolysaccharide‑induced acute respiratory distress syndrome and the associated inflammatory response by modulating the microRNA‑30a‑5p/PDE7A axis. Experimental and Therapeutic Medicine (2021)
IF = 4.174 The protective effects of Agomelatine against Aβ1-42 oligomers-induced cellular senescence mediated by SIRT6 and Agomelatine’s potential in AD treatment. Human Cell (2021)
IF = 5.714 4-Iodo-6-phenylpyrimidine (4-IPP) suppresses fibroblast-like synoviocyte- mediated inflammation and joint destruction associated with rheumatoid arthritis. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 1.785 Association between Nod‑like receptor protein 3 inflammasome and gouty nephropathy. Experimental and Therapeutic Medicine (2020)
IF = 2.892 Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo. CELL STRESS & CHAPERONES (2020)
IF = 6.208 Hyperglycemia Aggravates Periodontitis via Autophagy Impairment and ROS-Inflammasome-Mediated Macrophage Pyroptosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
IF = 1.871 Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells. Oncology Letters (2019)
IF = 1.645 LncRNA XIST knockdown ameliorates oxidative low-density lipoprotein-induced endothelial cells injury by targeting miR-204-5p/TLR4. JOURNAL OF BIOSCIENCES (2020)
IF = 3.244 miR‐141‐3p inhibits vascular smooth muscle cell proliferation and migration via regulating Keap1/Nrf2/HO‐1 pathway. IUBMB LIFE (2020)
IF = 2.336 MiR‐29c protects against inflammation and apoptosis in Parkinson's disease model in vivo and in vitro by targeting SP1. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2019)
IF = 3.758 Monocytes Undergo Functional Reprogramming to Generate Immunosuppression through HIF-1α Signaling Pathway in the Late Phase of Sepsis. MEDIATORS OF INFLAMMATION (2020)
IF = 2.928 NLRP3 inflammasome and lipid metabolism analysis based on UPLC-Q-TOF-MS in gouty nephropathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)
IF = 2.1 OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs. Molecular Medicine Reports (2020)
IF = 3.361 Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory responses. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 1.851 Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high‑glucose‑ and high‑insulin‑induced 3T3‑L1 adipocytes by promoting Nrf2 expression. Molecular Medicine Reports (2019)
IF = 3.553 Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)
IF = 2.628 Serum microtubule-associated protein light chain 3 type II levels correlate with aggravation and multi-organ dysfunction in septic patients. CHINESE MEDICAL JOURNAL (2021)
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IF = 27.287 The Akkermansia muciniphila Metabolite Harmaline Protects the Host From Systemic Viral Infection Through the Bile Acid-TGR5-NF-κB Axis. Cell Metabolism (2022)
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IF = 4.132 Weak UVB Irradiation Promotes Macrophage M2 Polarization and Stabilizes Atherosclerosis. Journal of Cardiovascular Translational Research (2021)
IF = 11.061 3D bioprinting of multi-cellular tumor microenvironment for prostate cancer metastasis. Biofabrication (2023)
IF = 6.376 4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes. MOLECULAR MEDICINE (2023)
IF = 4.369 A Cross-sectional Study Reveals a Chronic Low-grade Inflammation in Achalasia. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)
IF = 9.381 A novel polysaccharide from Lonicerae Japonicae Caulis: Characterization and effects on the function of fibroblast-like synoviocytes. CARBOHYDRATE POLYMERS (2022)
IF = 2.466 Advanced-platelet-rich fibrin extract promotes adipogenic and osteogenic differentiation of human adipose-derived stem cells in a dose-dependent manner in vitro. TISSUE & CELL (2021)
IF = 30.964 Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen. Nature Microbiology (2023)
IF = 1.277 Analgesic effect of TAK-242 on neuropathic pain in rats. International Journal of Clinical and Experimental Medicine (2015)
IF = 4.932 Anti-inflammatory activities of phospholipase C inhibitor U73122: Inhibition of monocyte-to-macrophage transformation and LPS-induced pro-inflammatory cytokine expression. INTERNATIONAL IMMUNOPHARMACOLOGY (2015)
IF = 2.73 Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2017)
IF = 3.659 Baicalein inhibits inflammatory response and promotes osteogenic activity in periodontal ligament cells challenged with lipopolysaccharides. BMC Complementary and Alternative Medicine (2021)
IF = 2.205 Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways. Bioengineered (2020)
IF = 3.758 CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway. MEDIATORS OF INFLAMMATION (2020)
IF = 5.168 Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines. Oncotarget (2017)
IF = 4.451 Chlorogenic acid improves intestinal barrier function by downregulating CD14 to inhibit the NF-κB signaling pathway. Journal of Functional Foods (2021)
IF = 3.978 CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression. NEUROTOXICITY RESEARCH (2022)
IF = 6.508 Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis. CANCER LETTERS (2019)
IF = 1.692 Comparison of morphology, phenotypes and function between cultured human IL‑4‑DC and IFN‑DC. Molecular Medicine Reports (2017)
IF = 4.927 Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway. MOLECULES (2023)
IF = 6.575 Consumption of Saturated Fatty Acids-Rich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR-γ. MOLECULAR NUTRITION & FOOD RESEARCH (2022)
IF = 16.874 Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis. Bioactive Materials (2022)
IF = 2.745 Cytotoxic effects of the benzophenanthridine alkaloids isolated from Eomecon chionantha on MCF-7 cells and its potential mechanism. CHEMISTRY & BIODIVERSITY (2022)
IF = 0.957 Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study. CHINESE MEDICAL JOURNAL (2016)
IF = 6.05 Different Effects of Endothelial Extracellular Vesicles and LPS-Induced Endothelial Extracellular Vesicles on Vascular Smooth Muscle Cells: Role of Curcumin and Its Derivatives. Frontiers in Cardiovascular Medicine (2021)
IF = 2.68 Dimethyl fumarate ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis through enhancing Nrf2 signaling. Toxicology Research (2022)
IF = 5.8 Discovery of a novel RIPK2 inhibitor for the treatment of inflammatory bowel disease. BIOCHEMICAL PHARMACOLOGY (2023)
IF = 8.101 Dopamine D1 receptor agonist alleviates acute lung injury via modulating inflammatory responses in macrophages and barrier function in airway epithelial cells. FREE RADICAL BIOLOGY AND MEDICINE (2023)
IF = 4.174 Down-regulation of long non-coding RNA XIST aggravates sepsis-induced lung injury by regulating miR-16-5p. Human Cell (2021)
IF = 3.319 Downregulation of MALAT1 alleviates saturated fatty acid-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-κB axis. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2019)
IF = 6.585 E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease. Journal of Crohns & Colitis (2016)
IF = 8.469 E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis. Cell Death & Disease (2022)
IF = 1.269 Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy. Experimental and Therapeutic Medicine (2015)
IF = 3.246 Effect of Orthodontic Combined with Implant Repair on Aesthetic Effect and Gingival Crevicular Fluid Factor in Patients with Dentition Defect and Periodontitis. Biomed Research International (2022)
IF = 0.716 Effect of soothing-liver and nourishing-heart acupuncture on early selective serotonin reuptake inhibitor treatment onset for depressive disorder and related indicators of neuroimmunology: a randomized controlled clinical trial. Journal of Traditional Chinese Medicine (2015)
IF = 3.448 Effects of β2/aβ2 on oxLDL-induced CD36 activation in THP-1 macrophages. LIFE SCIENCES (2019)
IF = 6.268 Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation. Communications Biology (2019)
IF = 5.486 Epstein-Barr virus envelope glycoprotein 110 inhibits NF-κB activation by interacting with NF-κB subunit p65. JOURNAL OF BIOLOGICAL CHEMISTRY (2023)
IF = 5.714 Eupalinolide B attenuates lipopolysaccharide-induced acute lung injury through inhibition of NF-κB and MAPKs signaling by targeting TAK1 protein. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 5.645 Evaluation of in vitro anti-acne activities of Ocimum basilicum L. water extract. INDUSTRIAL CROPS AND PRODUCTS (2022)
IF = 3.297 Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage. Annals of Translational Medicine (2020)
IF = 3.634 Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway. Frontiers in Endocrinology (2019)
IF = 3.078 Expression of RANKL by peripheral neutrophils and its association with bone mineral density in COPD. RESPIROLOGY (2016)
IF = 2.027 Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB. Journal of Thoracic Disease (2019)
IF = 5.646 Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
IF = 1.08 Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation. Molecular & Cellular Toxicology (2022)
IF = 3.064 FGL2 regulates IKK/NF-κB signaling in intestinal epithelial cells and lamina propria dendritic cells to attenuate dextran sulfate sodium-induced colitis. MOLECULAR IMMUNOLOGY (2019)
IF = 5.714 Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 15.153 Fluorous-Tagged Peptide Nanoparticles Ameliorate Acute Lung Injury via Lysosomal Stabilization and Inflammation Inhibition in Pulmonary Macrophages. Small (2022)
IF = 1.663 Fusobacterium nucleatum stimulates monocyte adhesion to and transmigration through endothelial cells. ARCHIVES OF ORAL BIOLOGY (2019)
IF = 6.575 Galangin targets HSP90β to alleviate ulcerative colitis by controlling fatty acid synthesis and subsequent NLRP3 inflammasome activation. MOLECULAR NUTRITION & FOOD RESEARCH (2023)
IF = 3.923 Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation. JOURNAL OF CELLULAR PHYSIOLOGY (2018)
IF = 4.932 GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 4.546 Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination. Chinese Medicine (2023)
IF = 5.391 Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly. FASEB JOURNAL (2019)
IF = 6.208 Glucokinase Inactivation Ameliorates Lipid Accumulation and Exerts Favorable Effects on Lipid Metabolism in Hepatocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
IF = 4.133 Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)
IF = 4.96 GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI. BIOCHEMICAL PHARMACOLOGY (2020)
IF = 2.547 Helicobacter pylori tumor necrosis factor-α inducing protein promotes cytokine expression via nuclear factor-κB. WORLD JOURNAL OF GASTROENTEROLOGY (2013)
IF = 3.758 hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro. MEDIATORS OF INFLAMMATION (2020)
IF = 2.367 Home-based exercise alters pulmonary function and cellular stress markers in overweight middle-aged men during covid-19 Home quarantine. BMC Sports Science Medicine and Rehabilitation (2023)
IF = 2.833 Hugan Qingzhi medication ameliorates free fatty acid-induced L02 hepatocyte endoplasmic reticulum stress by regulating the activation of PKC-δ. BMC Complementary and Alternative Medicine (2020)
IF = 3.144 Human bone marrow mesenchymal stem cells-derived exosomes protect against nerve injury via regulating immune microenvironment in neonatal hypoxic-ischemic brain damage model. IMMUNOBIOLOGY (2022)
IF = 3.153 Human Neural Stem Cell-Conditioned Medium Inhibits Inflammation in Macrophages Via Sirt-1 Signaling Pathway In Vitro and Promotes Sciatic Nerve Injury Recovery in Rats. STEM CELLS AND DEVELOPMENT (2020)
IF = 2.6 Huoxue Jiedu Recipe represses mitochondrial fission to alleviate submandibular gland inflammation in Sjögren's syndrome. MICROBIOLOGY AND IMMUNOLOGY (2023)
IF = 3.525 Hydrofluoric acid and nitric acid cotreatment for biofunctionalization of polyetheretherketone in M2 macrophage polarization and osteogenesis. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)
IF = 3.247 Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro. HUMAN & EXPERIMENTAL TOXICOLOGY (2023)
IF = 4.432 Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes. EUROPEAN JOURNAL OF PHARMACOLOGY (2021)
IF = 5.858 Identification of Tubocapsanolide A as a novel NLRP3 inhibitor for potential treatment of colitis. BIOCHEMICAL PHARMACOLOGY (2021)
IF = 2.333 IFN-DC Loaded with Autophagosomes containing Virus Antigen is Highly Efficient in Inducing Virus-Specific Human T Cells. International Journal of Medical Sciences (2019)
IF = 6.543 Impaired Autophagy Induced by oxLDL/β2GPI/anti-β2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction. Oxidative Medicine and Cellular Longevity (2021)
IF = 4.054 Impaired myeloid-derived suppressor cells are associated with recurrent implantation failure: A case-control study. JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)
IF = 4.927 Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process. MOLECULES (2022)
IF = 4.147 Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis. BONE (2020)
IF = 2.742 Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells. MOLECULAR BIOLOGY REPORTS (2023)
IF = 3.212 Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes. INFLAMMATION (2020)
IF = 3.146 Interleukin 1β and tumor necrosis factor α promote hFOB1.19 cell viability via activating AP1. American Journal of Translational Research (2016)
IF = 5.714 Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 5.156 Isopsoralen ameliorates rheumatoid arthritis by targeting MIF. ARTHRITIS RESEARCH & THERAPY (2021)
IF = 3.654 Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway. JOURNAL OF FOOD BIOCHEMISTRY (2023)
IF = 8.469 Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC. Cell Death & Disease (2021)
IF = 2.466 Lactate Transporter SLC16A3 (MCT4) as an Onco-Immunological Biomarker Associating Tumor Microenvironment and Immune Responses in Lung Cancer. International Journal of General Medicine (2022)
IF = 2.592 Levels of Interleukin-1β, Interleukin-18, and Tumor Necrosis Factor-α in Cerebrospinal Fluid of Aneurysmal Subarachnoid Hemorrhage Patients May Be Predictors of Early Brain Injury and Clinical Prognosis. World Neurosurgery (2017)
IF = 4.932 Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 5.6 LMCD1 is involved in tubulointerstitial inflammation in the early phase of renal fibrosis by promoting NFATc1-mediated NLRP3 activation. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 6.107 LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination. iScience (2022)
IF = 3.743 Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice. BIOMEDICINE & PHARMACOTHERAPY (2019)
IF = 5.037 MicroRNA-92a serves as a risk factor in sepsis-induced ARDS and regulates apoptosis and cell migration in lipopolysaccharide-induced HPMEC and A549 cell injury. LIFE SCIENCES (2020)
IF = 4.096 MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway. MOLECULAR MEDICINE (2020)
IF = 6.684 MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis. Frontiers in Cell and Developmental Biology (2021)
IF = 2.625 miR-155 promotes macrophage pyroptosis induced by Porphyromonas gingivalis through regulating the NLRP3 inflammasome. ORAL DISEASES (2019)
IF = 1.823 MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation. International Heart Journal (2022)
IF = 6.684 miR-513c-5p Suppression Aggravates Pyroptosis of Endothelial Cell in Deep Venous Thrombosis by Promoting Caspase-1. Frontiers in Cell and Developmental Biology (2022)
IF = 4.966 Mycobacterial PPE13 activates inflammasome by interacting with the NATCH and LRR domains of NLRP3. FASEB JOURNAL (2020)
IF = 7.419 Nanobody-based CAR T cells targeting intracellular tumor antigens. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 5.195 Network pharmacology-based prediction and verification of the active ingredients and potential targets of Huagan Decoction for reflux esophagitis. JOURNAL OF ETHNOPHARMACOLOGY (2022)
IF = 6.922 Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS. Journal of Inflammation Research (2021)
IF = 6.51 Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)
IF = 4.054 NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis. JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2022)
IF = 4.932 NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
IF = 1.76 NLRP3 inflammasome is required for apoptosis of Aggregatibacter actinomycetemcomitans-infected human osteoblastic MG63 cells. ACTA HISTOCHEMICA (2014)
IF = 7.419 Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota. BIOMEDICINE & PHARMACOTHERAPY (2023)
IF = 9.229 Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy. ACS Applied Materials & Interfaces (2021)
IF = 3.234 Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. LIFE SCIENCES (2018)
IF = 4.711 Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling. MEDIATORS OF INFLAMMATION (2021)
IF = 2.37 Overexpression of TRIM3 protects against LPS-induced acute kidney injury via repressing IRF3 pathway and NLRP3 inflammasome. INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)
IF = 5.784 Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus. FREE RADICAL BIOLOGY AND MEDICINE (2016)
IF = 0 Oxymatrine blocks the NLRP3 inflammasome pathway, partly downregulating the inflammatory responses of M1 macrophages differentiated from THP-1 monocytes. Biochemistry and Biophysics Reports (2023)
IF = 3.208 Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway. Drug Design Development and Therapy (2019)
IF = 2.472 Paeoniflorin down-regulates ATP-induced inflammatory cytokine production and P2X7R expression on peripheral blood mononuclear cells from patients with primary Sjögren's syndrome. INTERNATIONAL IMMUNOPHARMACOLOGY (2015)
IF = 5.714 Parthenolide alleviates microglia‐mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 4.24 Peptide WCPFSRSF ameliorates excitotoxicity and elevates synaptic plasticity in glutamate-damaged SH-SY5Y cells by modulating the PI3K/mTOR/EIF4E and BDNF/CREB/TrkB pathways. Food Bioscience (2022)
IF = 5.008 Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells. Oncotarget (2016)
IF = 3.149 Plasma biomarkers and delirium in critically ill patients after cardiac surgery: A prospective observational cohort study. HEART & LUNG (2023)
IF = 5.194 Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress. CHEMICO-BIOLOGICAL INTERACTIONS (2021)
IF = 3.5 Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression. Journal of Dental Sciences (2023)
IF = 5.168 Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy. Oncotarget (2017)
IF = 5.64 Progesterone Suppresses Neisseria gonorrhoeae-Induced Inflammation Through Inhibition of NLRP3 Inflammasome Pathway in THP-1 Cells and Murine Models. Frontiers in Microbiology (2021)
IF = 3.654 Promotion of angiogenesis in vitro by Astragalus polysaccharide via activation of TLR4 signaling pathway. JOURNAL OF FOOD BIOCHEMISTRY (2022)
IF = 6.53 Protective effect of total Saponins from American ginseng against cigarette smoke-induced COPD in mice based on integrated metabolomics and network pharmacology. BIOMEDICINE & PHARMACOTHERAPY (2022)
IF = 6.317 Protective mechanisms of Zanthoxylum Bungeanum essential oil on DSS-induced ulcerative colitis in mice based on colonic mucosal transcriptomic approach. Food & Function (2022)
IF = 6.175 Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy. Journal of Animal Science and Biotechnology (2022)
IF = 5.811 Puerarin Prevents Acute Liver Injury via Inhibiting Inflammatory Responses and ZEB2 Expression. Frontiers in Pharmacology (2021)
IF = 5.714 Quercetin protects endothelial function from inflammation induced by localized disturbed flow by inhibiting NRP2 -VEGFC complex. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
IF = 5.31 RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
IF = 5.293 RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus. Frontiers in Cellular and Infection Microbiology (2021)
IF = 3.876 Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation. Lipids in Health and Disease (2021)
IF = 11.161 RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)
IF = 6.317 Sennoside A is a novel inhibitor targeting caspase-1. Food & Function (2022)
IF = 3.642 SJMHE1 protects against excessive iodine-induced pyroptosis in human thyroid follicular epithelial cells through a toll-like receptor 2-dependent pathway. International Journal of Medical Sciences (2022)
IF = 5.31 Smoking increases oral mucosa susceptibility to Candida albicans infection via the Nrf2 pathway: In vitro and animal studies. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
IF = 3.84 SNHG15 knockdown inhibits diabetic nephropathy progression in pediatric patients by regulating the miR-141/ICAM-1 axis in vitro. BIOSCIENCE REPORTS (2021)
IF = 6.475 Structural characterization and anti-photoaging activity of a polysaccharide from Sargassum fusiforme. FOOD RESEARCH INTERNATIONAL (2022)
IF = 1.931 The anti-periodontitis action of metformin via targeting NLRP3 inflammasome. ARCHIVES OF ORAL BIOLOGY (2020)
IF = 6.304 The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression. Cell Death & Disease (2020)
IF = 4.221 The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration. TOXICOLOGY (2022)
IF = 2.264 Tilianin Protects against Nonalcoholic Fatty Liver Disease in Early Obesity Mice. BIOLOGICAL & PHARMACEUTICAL BULLETIN (2023)
IF = 7.397 TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome. IMMUNOLOGY (2022)
IF = 1.871 Time‑series clustering of cytokine expression after transarterial chemoembolization in patients with hepatocellular carcinoma. Oncology Letters (2019)
IF = 1.746 Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. JOURNAL OF MEMBRANE BIOLOGY (2019)
IF = 2.795 Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)
IF = 1.813 Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial. Evidence-based Complementary and Alternative Medicine (2020)
IF = 5.561 Ultra-High Hydrostatic Pressure Pretreatment on White Que Zui Tea: Chemical Constituents, Antioxidant, Cytoprotective, and Anti-Inflammatory Activities. Foods (2023)
IF = 5.682 Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis. Aging-US (2021)
IF = 5.895 Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)
IF = 1.261 Efficacy of arthroscopic loose body removal for knee osteoarthritis. Experimental and Therapeutic Medicine (2017)
IF = 2.942 Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway. BIOSCIENCE REPORTS (2020)
IF = 5.192 Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4/TXNIP-NLRP3-GSDMD pathway in ovarian cancer. FASEB JOURNAL (2022)
IF = 4.932 Demethoxycurcumin mitigates inflammatory responses in lumbar disc herniation via MAPK and NF-κB pathways in vivo and in vitro. INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
IF = 8.101 IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis. FREE RADICAL BIOLOGY AND MEDICINE (2022)
IF = 3.269 MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1. Bioengineered (2021)
IF = 6.244 MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI. Frontiers in Oncology (2021)
IF = 18.027 Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy. ACS Nano (2022)
IF = 9.986 NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. Redox Biology (2020)
IF = 5.631 Role of CXCL16 in BLM-induced epithelial–mesenchymal transition in human A549 cells. RESPIRATORY RESEARCH (2021)
IF = 8.755 The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway. CELL PROLIFERATION (2023)
IF = 2.447 Thioredoxin relieves lipopolysaccharide‑induced acute kidney injury in mice by reducing inflammation, oxidative stress and apoptosis. Experimental and Therapeutic Medicine (2021)
IF = 2.784 DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)
IF = 17.943 Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial. GUT (2019)
IF = 2.447 Effects of intranasal administration with Bacillus subtilis on immune cells in the nasal mucosa and tonsils of piglets. Experimental and Therapeutic Medicine (2018)
IF = 3.094 High Glucose-Induced Human Kidney Cell Apoptosis and Inflammatory Injury Are Alleviated by Circ_0008529 Knockdown via Circ_0008529-Mediated miR-485-5p/WNT2B Signaling. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)
IF = 1.872 Hypothermia Inhibits Cerebral Necroptosis and NOD-Like Receptor Pyrin Domain Containing 3 Pathway in a Swine Model of Cardiac Arrest. JOURNAL OF SURGICAL RESEARCH (2019)
IF = 10.793 IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)
IF = 2.583 Inflammatory Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Stem Cell-Like Characteristics of Cancer Cells in an IL-1β-Dependent Manner. Biomed Research International (2018)
IF = 1.894 Insulin Resistance Is Associated with Interleukin 1β (IL-1β) in Non-Diabetic Hemodialysis Patients. MEDICAL SCIENCE MONITOR (2018)
IF = 3.361 Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
IF = 4.174 Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis. Human Cell (2022)
IF = 3.342 MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes. INFECTION GENETICS AND EVOLUTION (2022)
IF = 3.212 Modulating macrophage polarization on titanium implant surface by poly(dopamine)-assisted immobilization of IL4. Clinical Implant Dentistry and Related Research (2019)
IF = 4.319 Study on the Mechanism of Improving HIV/AIDS Immune Function with Jian Aikang Concentrated Pill Based on Network Pharmacology Combined with Experimental Validation. Drug Design Development and Therapy (2022)
IF = 3.269 Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats. Bioengineered (2022)
IF = 6.384 Syndecan‐4 involves in the pathogenesis of rheumatoid arthritis by regulating the inflammatory response and apoptosis of fibroblast‐like synoviocytes. JOURNAL OF CELLULAR PHYSIOLOGY (2019)
IF = 6.543 Exogenous Parathyroid Hormone Alleviates Intervertebral Disc Degeneration through the Sonic Hedgehog Signalling Pathway Mediated by CREB. Oxidative Medicine and Cellular Longevity (2022)

杭州联科生物技术股份有限公司

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背景介绍	白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1β是活化的巨噬细胞分泌的蛋白前体，通过caspase1(CASP1/ICE)水解产生的活化形式。该细胞因子是炎症反应的重要介导者，参与许多细胞活性，包括细胞增殖、分化和凋亡。IL-1是一类重要的蛋白家族，它们由生物活化的单核细胞所衍生，参与炎症反应和免疫应答。IL-1β表达升高会产生各种不同的自身炎症综合征，最显著的是单基因条件称为CAPS，是由于触发IL-1β加工的炎性体受体NLRP3发生突变而引起的。本试剂盒用来检测人IL-1β的成熟形式和未裂解的前体形式。
检测原理	本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-1β抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的IL-1β与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后，加入信号增强剂孵育，洗涤去除未结合的物质后，再次加入Streptavidin-HRP。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-1β的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。
组分	包被抗IL-1β单克隆抗体的96孔聚苯乙烯酶标板人IL-1β冻干标准品 IL-1β检测抗体标准品稀释液辣根过氧化物酶标记的链霉亲和素信号增强剂浓缩液信号增强剂稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜
分析类型	夹心ELISA
样本类型	血清、血浆，细胞培养上清及其他生物学样本
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
样本体积	20 μl
灵敏度	0.02 pg/ml
标曲图
标准曲线范围	0.19 - 12 pg/ml
回收率范围	93 % - 112 %
平均回收率	1.02
板间变异系数	2.3 % - 8.9 %
板内变异系数	4.5 % - 5.6 %