E3泛素蛋白连接酶亚基KPC2抗体

供应商 ：江西江蓝纯生物试剂有限公司

库存 ：28

克隆性 ：单克隆

保质期 ：1年

抗体英文名 ：KPC2

抗体名 ：E3泛素蛋白连接酶亚基KPC2抗体

适应物种 ：人/动物/植物

应用范围 ：WB,ELISA等

浓度 ：1mg/ml

保存条件 ：-20 °

规格 ：100ul/200ul

产品货号 :  jlcR16801
英文名称 :  KPC2
中文名称 :  E3泛素蛋白连接酶亚基KPC2抗体
别    名 :  UBAC1_HUMAN; Ubiquitin-associated domain-containing protein 1; UBA domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2.   
研究领域 :  细胞生物  泛素  
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应 :  Human, Mouse, Rat, Cow, Sheep,
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 :  45kDa
细胞定位 :  细胞浆
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免 疫 原 :  KLH conjugated synthetic peptide derived from human KPC2:321-405/405
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍background:
KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G1 phase of the cell cycle. KPC2 contains a ubiquitin-like (UBL) domain, two ubiquitin-associated (UBA) domains, and a heat shock chaperonin-binding (STI1) domain.

Function:
Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Subunit:
Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain.

Subcellular Location:
Cytoplasmic

Similarity:
Ubiquitous.
Contains 1 STI1 domain.
Contains 2 UBA domains.
Contains 1 ubiquitin-like domain.

SWISS:
Q9BSL1

Gene ID:
10422

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.