TIMP2 Polyclonal Antibody

克隆性 ：多克隆

宿主 ：Rabbit

适应物种 ：Human,Mouse,Rat

亚型 ：IgG

形态 ：Lyophilized or Liquid

应用范围 ：WB,IF,ELISA

保存条件 ：-20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

规格 ：10μl/20μl/50μl/100μl

Product Information： 

Product name	TIMP2 Polyclonal Antibody
Isotype	IgG
Form	Lyophilized or Liquid
Tested applications	WB,IF,ELISA
Species reactivity	Human,Mouse,Rat
Host Species	Rabbit
Purity	Affinity purification

 

Immunogen Information：

  

Immunogen	A synthetic peptide of human TIMP2
Calculated molecular weight	24kDa
Observed molecular weight	26kDa
Swiss Prot	P16035
Gene ID (NCBI)	7077
Alternative Names	TIMP2; CSC-21K; DDC8; metalloproteinase inhibitor 2

 

Application Notes：

 

WB	1:500 - 1:2000
IF	1:50 - 1:200

                                 

Western blot analysis of extracts of various cell lines, using TIMP2 antibody.

Immunofluorescence analysis of MCF-7 cells using TIMP2 antibody.

 

 

Background：

 

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.    

 

Storage：

 

Storage instructions

Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.