阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体价格

供应商：江西江蓝纯生物试剂有限公司

库存：64

克隆性：单克隆

保质期：1年

抗体英文名：CLACP

抗体名：阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体

适应物种：人/动物/植物

应用范围：WB,ELISA等

浓度：1mg/ml

保存条件：-20 °

规格：100ul/200ul

产品货号 : jlcR11643
英文名称 : CLACP
中文名称 : 阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体
别    名 : Alzheimer disease amyloid associated protein; AMY; CLAC; CLAC P; CLAC precursor; COL25A1; COL25A1 protein; Collagen alpha 1 XXV chain; Collagen alpha 1(XXV) chain; Collagen like Alzheimer amyloid plaque component; Collagen like Alzheimer amyloid plaque component precursor; Collagen type XXV alpha 1; Collagenous Alzheimer amyloid plaque component.
研究领域 : 神经生物学 Alzheimer's
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 :   Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 : 65kDa
细胞定位 : 细胞膜分泌型蛋白
性    状 : Lyophilized or Liquid
浓    度 : 1mg/ml
免疫原 : KLH conjugated synthetic peptide derived from human CLACP:581-654/654 <Extracellular>
亚    型 : IgG
纯化方法 : affinity purified by Protein A
储存液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 :   Collagen proteins (products of the COL gene family) are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. The Collagen Type XXV precursor produces the proteolytic fragment CLAC (collagenous Alzheimer amyloid plaque component), which deposits in senile plaques associated with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease. CLAC binds to the fibrillized form of Abeta, which disturbs the structure and function of plasma membranes.

Function:
Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's diseased (AD) brains. The 9D2 antigen was identified as CLAC (collagen like Alzheimer amyloid plaque component), and its precursor as CLACP/collagen type XXV. Both secreted and membrane tethered forms of CLACP/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta amyloidogenesis and neuronal degeneration in AD.

Subunit:
o assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. [SUBUNIT] Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential). Note=After proteolytic cleavage, CLAC is secreted.

Tissue Specificity:
Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.

Post-translational modifications:
Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.
Glycosylated.
Hydroxylated on 11% of proline residues and 49% of lysine residues.

Similarity:
Contains 7 collagen-like domains.

SWISS:
Q9BXS0

Gene ID:
84570

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片