P5C还原酶1抗体

供应商 ：江西江蓝纯生物试剂有限公司

库存 ：137

克隆性 ：单克隆

保质期 ：1年

抗体英文名 ：PYCR1

抗体名 ：P5C还原酶1抗体

适应物种 ：人/动物/植物

应用范围 ：WB,ELISA等

浓度 ：1mg/ml

保存条件 ：-20 °

规格 ：100ul/200ul

产品货号 :  jlcR20864
英文名称 :  PYCR1
中文名称 : P5C还原酶1抗体
别    名 :  P5C; P5C reductase 1; P5C reductase; P5CR 1; P5CR; PIG45; PP222; Proliferation inducing protein 45; PYCR 1; PYCR; Pyrroline 5 carboxylate reductase 1; Pyrroline 5 carboxylate reductase 1 mitochondrial.  
研究领域 :  肿瘤  发育生物学  信号转导  线粒体  
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应  :  Mouse, Rat,
产品应用 :  WB=1:500-2000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 :  33kDa
细胞定位 :  细胞浆 线粒体
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免 疫 原 :  KLH conjugated synthetic peptide derived from mouse PYCR1:241-309/309
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍 :   This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Function:
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.

Subunit:
Homodecamer; composed of 5 homodimers.

Subcellular Location:
Mitochondrial

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Patients do not manifest metabolic abnormalities.

Similarity:
Belongs to the pyrroline-5-carboxylate reductase family.

SWISS:
Q922W5

Gene ID:
209027

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片