ombinant,Human IL-1Ra，重组人IL-1Ra

价格： ￥1140

品牌：Peprotech

货号：YJ200-01RA

产品详情

Recombinant Human IL-1Ra

产品编号:

200-01RA

别名:

IL-1Ra,ICIL-1RA,IRAP,IL-1RN

描述:

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.

氨基酸序列:

MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

来源:

E.coli

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED₅₀ is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.