AZD1080(612487-72-6)(≥98%)

AZD1080(612487-72-6)(≥98%)

价格： ¥380 - 3800

品牌：百奥莱博

货号：L10090-YWO

产品详情

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库存：156

英文名：AZD1080

CAS号：612487-72-6

保质期：长期

供应商：北京百奥莱博科技有限公司

保存条件：-20℃

规格：5mg|25mg

特别提示：包括AZD1080在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：AZD1080
英文名称：AZD1080
产品货号：L10090
产品规格：5mg|25mg

属性

CAS号	612487-72-6
分子式	C₁₉H₁₈N₄O₂
分子量	334.37
溶解性	DMSO 52mg/mL Water<1 mg/mL Ethanol<1 mg/mL
存贮条件	储存温度-20℃

描述

产品介绍	AZD1080是口服活性的可通透脑屏障的GSK3α和GSK3β抑制剂，Ki分别为6.9 nM和31 nM。
备注	AZD1080 is a selective,orally active,brain permeableGSK3inhibitor,inhibits human GSK3α and GSK3β withK_iof 6.9 nM and 31 nM,respectively,shows>14-fold selectivity against CDK2,CDK5,CDK1 and Erk2.
生化机理	Description: IC50 Value:31 nM[1] AZD1080 is a potent and selective GSK3 inhibitor that demonstrates peripheral target engagement in Phase 1 clinical studies. in vitro:AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain.Interestingly,subchronic but not acute administration with AZD1080 reverses MK-801-induced deficits,measured by long-term potentiation in hippocampal slices and in a cognitive test in mice,suggesting that reversal of synaptic plasticity deficits in dysfunctional systems requires longer term modifications of proteins downstream of GSK3βsignaling[1]. in vivo:AZD1080 reverses MK-801-induced impairments in mouse model of cognition.AZD1080 treatment significantly prevents MK-801-induced deficits at both time-points(p<0.05;*p<0.01).Data are presented as mean _ SEM(n = 9-12 subjects/group).[1] Clinical trial:Phase 1
别名	2-羟基-3-[5-[(mǎ啉-4-基)甲基]bǐ啶-2-基]-1H-吲哚-5-甲腈;HY-13862;AZD-1080;AZD 1080;2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile

我公司销售的AZD1080(612487-72-6)(≥98%)，HY-13862，2-羟基-3-[5-[(mǎ啉-4-基)甲基]bǐ啶-2-基]-1H-吲哚-5-甲腈，AZD 1080，2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile，AZD-1080质量上佳，价格普惠，欢迎广大新老客户踊跃订购。

北京百奥莱博科技有限公司

实名认证

钻石会员

入驻年限：9年

联系人：王欣

地址：北京

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